Determination of d‐limonene in mice plasma and tissues by a new GC–MS/MS method: Comparison of the pharmacokinetics and tissue distribution by oral and inhalation administration in mice
The aim of the present study was to develop a method based on gas chromatography–tandem mass spectrometry (GC–MS/MS) to determine and quantify the d‐limonene in mouse plasma and tissue samples. This new method was validated for the quantification of d‐limonene with the linearity ranges 1.0–1000.0 ng...
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| Veröffentlicht in: | Biomedical chromatography 2019-07, Vol.33 (7), p.e4530-n/a |
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| container_title | Biomedical chromatography |
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| creator | Chen, Chen Sheng, Yunhua Hu, Yue Sun, Jie Li, Wei Feng, Hongmin Tang, Liming |
| description | The aim of the present study was to develop a method based on gas chromatography–tandem mass spectrometry (GC–MS/MS) to determine and quantify the d‐limonene in mouse plasma and tissue samples. This new method was validated for the quantification of d‐limonene with the linearity ranges 1.0–1000.0 ng/mL (r2 > 0.9952) for plasma samples and 5.0–5000.0 ng/g (r2 > 0.9940) for tissue samples. The intra‐ and inter‐day assay of precisions in plasma and tissues were kidney > heart > lung > spleen). |
| doi_str_mv | 10.1002/bmc.4530 |
| format | Article |
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This new method was validated for the quantification of d‐limonene with the linearity ranges 1.0–1000.0 ng/mL (r2 > 0.9952) for plasma samples and 5.0–5000.0 ng/g (r2 > 0.9940) for tissue samples. The intra‐ and inter‐day assay of precisions in plasma and tissues were <13.4% and the accuracies were within 91.1–105.8%. In the oral/inhalation administration pharmacokinetics and tissue distribution studies, the main pharmacokinetic parameters were the peak concentration = (97.150 ± 34.450)/(4336.415 ± 1142.418) ng/mL, the area under the curve = (162.828± 27.447)/(2085.721 ± 547.787) h ng/mL and the half‐life = (3.196 ± 0.825)/(0.989 ± 0.095) h. The tissue distribution of d‐limonene in mice after oral/inhalation administration demonstrated a decreasing tendency in different tissues (liver > kidney > heart > lung > spleen).</description><identifier>ISSN: 0269-3879</identifier><identifier>EISSN: 1099-0801</identifier><identifier>DOI: 10.1002/bmc.4530</identifier><identifier>PMID: 30845345</identifier><language>eng</language><publisher>England</publisher><subject>d‐limonene ; gas chromatography–tandem mass spectrometry ; pharmacokinetics ; tissue distribution</subject><ispartof>Biomedical chromatography, 2019-07, Vol.33 (7), p.e4530-n/a</ispartof><rights>2019 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3210-436a2f786e59e8c1e3471776fa047b1c20354eae5c25f593a463a872469fa61d3</citedby><cites>FETCH-LOGICAL-c3210-436a2f786e59e8c1e3471776fa047b1c20354eae5c25f593a463a872469fa61d3</cites><orcidid>0000-0002-7970-7951</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbmc.4530$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbmc.4530$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30845345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Sheng, Yunhua</creatorcontrib><creatorcontrib>Hu, Yue</creatorcontrib><creatorcontrib>Sun, Jie</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Feng, Hongmin</creatorcontrib><creatorcontrib>Tang, Liming</creatorcontrib><title>Determination of d‐limonene in mice plasma and tissues by a new GC–MS/MS method: Comparison of the pharmacokinetics and tissue distribution by oral and inhalation administration in mice</title><title>Biomedical chromatography</title><addtitle>Biomed Chromatogr</addtitle><description>The aim of the present study was to develop a method based on gas chromatography–tandem mass spectrometry (GC–MS/MS) to determine and quantify the d‐limonene in mouse plasma and tissue samples. This new method was validated for the quantification of d‐limonene with the linearity ranges 1.0–1000.0 ng/mL (r2 > 0.9952) for plasma samples and 5.0–5000.0 ng/g (r2 > 0.9940) for tissue samples. The intra‐ and inter‐day assay of precisions in plasma and tissues were <13.4% and the accuracies were within 91.1–105.8%. In the oral/inhalation administration pharmacokinetics and tissue distribution studies, the main pharmacokinetic parameters were the peak concentration = (97.150 ± 34.450)/(4336.415 ± 1142.418) ng/mL, the area under the curve = (162.828± 27.447)/(2085.721 ± 547.787) h ng/mL and the half‐life = (3.196 ± 0.825)/(0.989 ± 0.095) h. The tissue distribution of d‐limonene in mice after oral/inhalation administration demonstrated a decreasing tendency in different tissues (liver > kidney > heart > lung > spleen).</description><subject>d‐limonene</subject><subject>gas chromatography–tandem mass spectrometry</subject><subject>pharmacokinetics</subject><subject>tissue distribution</subject><issn>0269-3879</issn><issn>1099-0801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kUtOwzAQhi0EglKQOAHykk2oHefJDsJTomJRWEcTZ6IaYqeyU1Xd9QhInIfL9CSkDSA2rEaj-fTp1_yEnHB2zhnzR4WW50Eo2A4ZcJamHksY3yUD5kepJ5I4PSCHzr0yxtLIj_fJgWBJhwfhgHxeY4tWKwOtagxtKlquV--10o1Bg1QZqpVEOqvBaaBgStoq5-boaLGkQA0u6F22Xn2MJ6PxhGpsp015QbNGz8Aq1xvbaSeYgtUgmzdlsFXS_VHRUrnWqmK-TdBpGwv19q7MFOo-GJRdxg3Xr9-5jsheBbXD4-85JC-3N8_Zvff4dPeQXT56UviceYGIwK_iJMIwxURyFEHM4ziqgAVxwaXPRBggYCj9sApTAUEkIIn9IEoriHgphuSs90rbOGexymdWabDLnLN800DeNZBvGujQ0x6dzQuN5S_48_IO8HpgoWpc_ivKr8bZVvgFUWSUSg</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Chen, Chen</creator><creator>Sheng, Yunhua</creator><creator>Hu, Yue</creator><creator>Sun, Jie</creator><creator>Li, Wei</creator><creator>Feng, Hongmin</creator><creator>Tang, Liming</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-7970-7951</orcidid></search><sort><creationdate>201907</creationdate><title>Determination of d‐limonene in mice plasma and tissues by a new GC–MS/MS method: Comparison of the pharmacokinetics and tissue distribution by oral and inhalation administration in mice</title><author>Chen, Chen ; Sheng, Yunhua ; Hu, Yue ; Sun, Jie ; Li, Wei ; Feng, Hongmin ; Tang, Liming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3210-436a2f786e59e8c1e3471776fa047b1c20354eae5c25f593a463a872469fa61d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>d‐limonene</topic><topic>gas chromatography–tandem mass spectrometry</topic><topic>pharmacokinetics</topic><topic>tissue distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Sheng, Yunhua</creatorcontrib><creatorcontrib>Hu, Yue</creatorcontrib><creatorcontrib>Sun, Jie</creatorcontrib><creatorcontrib>Li, Wei</creatorcontrib><creatorcontrib>Feng, Hongmin</creatorcontrib><creatorcontrib>Tang, Liming</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Biomedical chromatography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chen</au><au>Sheng, Yunhua</au><au>Hu, Yue</au><au>Sun, Jie</au><au>Li, Wei</au><au>Feng, Hongmin</au><au>Tang, Liming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of d‐limonene in mice plasma and tissues by a new GC–MS/MS method: Comparison of the pharmacokinetics and tissue distribution by oral and inhalation administration in mice</atitle><jtitle>Biomedical chromatography</jtitle><addtitle>Biomed Chromatogr</addtitle><date>2019-07</date><risdate>2019</risdate><volume>33</volume><issue>7</issue><spage>e4530</spage><epage>n/a</epage><pages>e4530-n/a</pages><issn>0269-3879</issn><eissn>1099-0801</eissn><abstract>The aim of the present study was to develop a method based on gas chromatography–tandem mass spectrometry (GC–MS/MS) to determine and quantify the d‐limonene in mouse plasma and tissue samples. This new method was validated for the quantification of d‐limonene with the linearity ranges 1.0–1000.0 ng/mL (r2 > 0.9952) for plasma samples and 5.0–5000.0 ng/g (r2 > 0.9940) for tissue samples. The intra‐ and inter‐day assay of precisions in plasma and tissues were <13.4% and the accuracies were within 91.1–105.8%. In the oral/inhalation administration pharmacokinetics and tissue distribution studies, the main pharmacokinetic parameters were the peak concentration = (97.150 ± 34.450)/(4336.415 ± 1142.418) ng/mL, the area under the curve = (162.828± 27.447)/(2085.721 ± 547.787) h ng/mL and the half‐life = (3.196 ± 0.825)/(0.989 ± 0.095) h. The tissue distribution of d‐limonene in mice after oral/inhalation administration demonstrated a decreasing tendency in different tissues (liver > kidney > heart > lung > spleen).</abstract><cop>England</cop><pmid>30845345</pmid><doi>10.1002/bmc.4530</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7970-7951</orcidid></addata></record> |
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| issn | 0269-3879 1099-0801 |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | d‐limonene gas chromatography–tandem mass spectrometry pharmacokinetics tissue distribution |
| title | Determination of d‐limonene in mice plasma and tissues by a new GC–MS/MS method: Comparison of the pharmacokinetics and tissue distribution by oral and inhalation administration in mice |
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