Simple determination of plasma ibrutinib concentration using high‐performance liquid chromatography

Ibrutinib is an oral inhibitor of Bruton tyrosine kinase, which is one of the key drugs used for the treatment of chronic lymphocytic leukemia and mantle cell lymphoma. In this study, we aimed to develop a simple method for determining plasma ibrutinib concentration. The analysis required extraction...

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Veröffentlicht in:	Biomedical chromatography 2019-03, Vol.33 (3), p.e4435-n/a
Hauptverfasser:	Yasu, Takeo, Momo, Kenji, Yasui, Hiroshi, Kuroda, Seiichirou
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, High Pressure Liquid - methods HPLC‐UV detection method human plasma concentration Humans ibrutinib Limit of Detection Linear Models nilotinib Pyrazoles - blood Pyrazoles - chemistry Pyrazoles - pharmacokinetics Pyrimidines - blood Pyrimidines - chemistry Pyrimidines - pharmacokinetics Reproducibility of Results
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