Screening and identification of metabolites of two kinds of main active ingredients and hepatotoxic pyrrolizidine alkaloids in rat after lavage Farfarae Flos extract by UHPLC‐Q‐TOF‐MS mass spectrometry

Farfarae Flos, the dried flower buds of Tussilago farfara L., is usually used to treat coughs, bronchitic and asthmatic conditions as an important traditional Chinese medicine. Tussilagone and methl butyric acid tussilagin ester are seen as representatives of two kinds of active substances. In addit...

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Veröffentlicht in:	Biomedical chromatography 2018-02, Vol.32 (2), p.n/a
Hauptverfasser:	Cheng, Xiaoye, Liao, Man, Diao, Xinpeng, Sun, Yupeng, Zhang, Lantong
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Asteraceae - chemistry Bile - chemistry Chromatography, High Pressure Liquid - methods Drugs, Chinese Herbal - administration & dosage Drugs, Chinese Herbal - analysis Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacokinetics Farfarae Flos extract Feces - chemistry Male metabolites pyrrolizidine alkaloids Pyrrolizidine Alkaloids - analysis Pyrrolizidine Alkaloids - chemistry Pyrrolizidine Alkaloids - pharmacokinetics Rats Rats, Sprague-Dawley sesquiterpenes Sesquiterpenes - analysis Sesquiterpenes - chemistry Sesquiterpenes - pharmacokinetics Tandem Mass Spectrometry - methods UHPLC‐q‐TOF‐MS/MS
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