Technologies and strategies to characterize and quantitate metabolites in drug discovery and development

ABSTRACT Pharmacokinetics and toxicokinetics studies rely on the quantitation of drugs and its metabolites. Drug metabolism studies are based on the characterization of the structure of drugs and their metabolites. Liquid chromatography coupled with mass spectrometry is an undisputed technology for...

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Veröffentlicht in:	Biomedical chromatography 2014-11, Vol.28 (11), p.1547-1553
Hauptverfasser:	Ravindran, Selvan, Jadhav, Amol, Surve, Prashant, Lonsane, Ganesh, Honrao, Pradnya, Nanda, Bidyut
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Liquid - methods drug discovery Drug Discovery - methods liquid chromatography mass spectrometry Mass Spectrometry - methods metabolites Pharmaceutical Preparations - analysis Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - metabolism technologies
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