Measurement of S-methylcysteine and S-methyl-mercapturic acid in human urine by alkyl-chloroformate extractive derivatization and isotope-dilution gas chromatography-mass spectrometry

S‐methylcysteine (SMC) is a minor amino acid naturally excreted in human urine, a protective agent against oxidative stress and a biotransformation product of the fumigant biocide methyl bromide and of nicotine. A metabolic source of SMC is catabolism of the repair catalytic protein MGMT (EC 2.1.1.3...

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Veröffentlicht in:	Biomedical chromatography 2011-03, Vol.25 (3), p.330-343
Hauptverfasser:	Rubino, Federico M, Pitton, Marco, Di Fabio, Daniela, Meroni, Giuseppe, Santaniello, Enzo, Caneva, Enrico, Pappini, Marco, Colombi, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - analogs & derivatives Acetylcysteine - urine Adult Biomarkers Calibration Cysteine - analogs & derivatives Cysteine - urine Female Formates - chemistry Gas Chromatography-Mass Spectrometry - methods Humans Husek derivatization isotope dilution Linear Models Male Methylhistidines Reproducibility of Results S-methyl-cysteine S-methyl-mercapturic acid Sensitivity and Specificity urine
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