Engineering Pichia pastoris to improve S‐adenosyl‐ l‐methionine production using systems metabolic strategies

S‐adenosyl‐l‐methionine (SAM) is a highly valued chemical that can be used as a dietary supplement and has been used to treat depression, osteoarthritis, and liver problems as well. We adopted systems metabolic engineering strategies to improve SAM production in a high‐producing strain (GS115/DS56)....

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Veröffentlicht in:	Biotechnology and bioengineering 2020-05, Vol.117 (5), p.1436-1445
Hauptverfasser:	Qin, Xiulin, Lu, Junjie, Zhang, Yin, Wu, Xiaole, Qiao, Xuefeng, Wang, Zhipeng, Chu, Ju, Qian, Jiangchao
Format:	Artikel
Sprache:	eng
Schlagworte:	Auxotrophy Biomedical materials Diet Dietary supplements Fermentation Gene deletion Homocysteine Industrial production Metabolic engineering Metabolism Methionine Osteoarthritis Pichia pastoris promoter library S‐adenosyl‐L‐methionine transcriptome profiling
Online-Zugang:	Volltext
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