A dynamic model linking cell growth to intracellular metabolism and extracellular by‐product accumulation

Mathematical modeling of animal cell growth and metabolism is essential for the understanding and improvement of the production of biopharmaceuticals. Models can explain the dynamic behavior of cell growth and product formation, support the identification of the most relevant parameters for process...

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Veröffentlicht in:	Biotechnology and bioengineering 2020-05, Vol.117 (5), p.1533-1553
Hauptverfasser:	Ramos, João R. C., Rath, Alexander G., Genzel, Yvonne, Sandig, Volker, Reichl, Udo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Ammonium animal cell ATP Biotechnology & Applied Microbiology Case studies Cell growth Cell size Citric acid Computer simulation Culture media Design parameters Differential equations dynamic model Dynamic models Glycolysis Intracellular Ketoglutaric acid kinetic Lactic acid Life Sciences & Biomedicine Mathematical models Metabolism Metabolites Optimization Ordinary differential equations Parameter identification Physiology Process parameters Science & Technology Substrates TCA cycle Tricarboxylic acid cycle
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