Real-time dissolved carbon dioxide monitoring I: Application of a novel in situ sensor for CO 2 monitoring and control

Dissolved carbon dioxide (dCO ) is a well-known critical parameter in bioprocesses due to its significant impact on cell metabolism and on product quality attributes. Processes run at small-scale faces many challenges due to limited options for modular sensors for online monitoring and control. Trad...

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Veröffentlicht in:	Biotechnology and bioengineering 2020-04, Vol.117 (4), p.981-991
Hauptverfasser:	Chopda, Viki R, Holzberg, Timothy, Ge, Xudong, Folio, Brandon, Tolosa, Michael, Kostov, Yordan, Tolosa, Leah, Rao, Govind
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioreactors Biotechnology - instrumentation Biotechnology - methods Calibration Carbon Dioxide - analysis Carbon Dioxide - metabolism Equipment Design Glucose - metabolism Oxygen - metabolism Saccharomyces cerevisiae - metabolism Yarrowia - metabolism
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