Fermentation of Bacillus thuringiensis for exotoxin production: Process analysis study

The exotoxin produced by certain serotypes of Bacillus thuringiensis was used as a means of microbiological control of the larval development of flies. The optimal batch cultivation conditions with respect to pH, temperature, aeration, agitation, and initial concentration of growth‐limiting substrat...

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Veröffentlicht in:Biotechnology and bioengineering 1980-08, Vol.22 (8), p.1707-1724
Hauptverfasser: Holmberg, Andrea, Sievänen, Risto, Carlberg, Gunnel
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container_issue 8
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container_title Biotechnology and bioengineering
container_volume 22
creator Holmberg, Andrea
Sievänen, Risto
Carlberg, Gunnel
description The exotoxin produced by certain serotypes of Bacillus thuringiensis was used as a means of microbiological control of the larval development of flies. The optimal batch cultivation conditions with respect to pH, temperature, aeration, agitation, and initial concentration of growth‐limiting substrate were determined. A dynamic model describing the process was designed and fitted to the experimental data. The application of a method for estimating exotoxin and bacterial concentrations from on‐line measurable quantities such as oxygen consumption and heat production is presented.
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title Fermentation of Bacillus thuringiensis for exotoxin production: Process analysis study
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