Evidence for the role of Th17 cell inhibition in the prevention of autoimmune diseases by anti-interluekin-6 receptor antibody

Deregulated production of interleukin‐6 (IL‐6) has been found in several chronic inflammatory autoimmune disorders, including rheumatoid arthritis (RA) and inflammatory bowel diseases. Treatment with tocilizumab, a humanized anti‐human IL‐6 receptor (IL‐6R) antibody, significantly improved disease a...

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Veröffentlicht in:	BioFactors (Oxford) 2009-01, Vol.35 (1), p.47-51
Hauptverfasser:	Mihara, Masahiko, Ohsugi, Yoshiyuki, Kishimoto, Tadamitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-IL-6R antibody Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Autoimmune Diseases - drug therapy Autoimmune Diseases - immunology Autoimmune Diseases - prevention & control Cell Differentiation Humans Interleukin-6 - metabolism Mice Models, Biological Receptors, Interleukin-6 - antagonists & inhibitors Receptors, Interleukin-6 - immunology rheumatoid arthritis T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocytes, Helper-Inducer - immunology Th1 Th17
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