Statistically Estimated Free Energies of Chromosome Aberration Production from Frequency Data

Janardan and Schaeffer (1977) suggested that the Lagrangian Poisson Distribution (LPD) could be used to estimate the net free energy for the production of induced chromosome aberrations. Using a Markov‐chain model, a formal link between the LPD and the thermodynamic free energy is now provided. It i...

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Veröffentlicht in:Biometrical journal 1983, Vol.25 (3), p.275-282
Hauptverfasser: Schaeffer, D. J., Janardan, K. G., Kerster, H. W., Clarke, A. C. M.
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container_end_page 282
container_issue 3
container_start_page 275
container_title Biometrical journal
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creator Schaeffer, D. J.
Janardan, K. G.
Kerster, H. W.
Clarke, A. C. M.
description Janardan and Schaeffer (1977) suggested that the Lagrangian Poisson Distribution (LPD) could be used to estimate the net free energy for the production of induced chromosome aberrations. Using a Markov‐chain model, a formal link between the LPD and the thermodynamic free energy is now provided. It is estimated that the free energy required to produce isochromatid breaks or dicentrics is about 3.67 KJ/mole/aberration and 18.4 KJ/mole, in good agreement with free energy estimates on the formation of DNA.
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subjects Lagrangian Poisson distribution
Markov‐chain model
title Statistically Estimated Free Energies of Chromosome Aberration Production from Frequency Data
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