Environmental agents affect skeletal growth and development
In this treatise we will examine complexities in the development and function of cells of the musculoskeletal system. Specifically, the role of chondrocytes and their ontogeny and osteoblasts and their ontogeny will be discussed as they regulate cartilage and bone formation. This background informat...
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| Veröffentlicht in: | Birth defects research. Part C. Embryo today 2007-03, Vol.81 (1), p.41-50 |
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| container_title | Birth defects research. Part C. Embryo today |
| container_volume | 81 |
| creator | Holz, Jonathan D. Sheu, Tzong-jen Drissi, Hicham Matsuzawa, Mitsuhiro Zuscik, Michael J. Puzas, J. Edward |
| description | In this treatise we will examine complexities in the development and function of cells of the musculoskeletal system. Specifically, the role of chondrocytes and their ontogeny and osteoblasts and their ontogeny will be discussed as they regulate cartilage and bone formation. This background information will provide the foundation for evaluating the effects of environmental toxicants on skeletal development. A number of agents such as heavy metals (i.e. lead) and polycyclic aromatic hydrocarbons (i.e. pesticides and cigarette smoke) interact with cells of the skeletal system and adversely affect development. These agents have not been of major research interest, nevertheless, given changes in the environmental profile of the United States and other developed countries, it is important that we understand their effects in bone and cartilage. Research in this area will identify strategies that may be used to help prevent musculoskeletal diseases due to toxicant exposure. Birth Defects Research (Part C) 81:41–50, 2007. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/bdrc.20087 |
| format | Article |
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Edward</creator><creatorcontrib>Holz, Jonathan D. ; Sheu, Tzong-jen ; Drissi, Hicham ; Matsuzawa, Mitsuhiro ; Zuscik, Michael J. ; Puzas, J. Edward</creatorcontrib><description>In this treatise we will examine complexities in the development and function of cells of the musculoskeletal system. Specifically, the role of chondrocytes and their ontogeny and osteoblasts and their ontogeny will be discussed as they regulate cartilage and bone formation. This background information will provide the foundation for evaluating the effects of environmental toxicants on skeletal development. A number of agents such as heavy metals (i.e. lead) and polycyclic aromatic hydrocarbons (i.e. pesticides and cigarette smoke) interact with cells of the skeletal system and adversely affect development. These agents have not been of major research interest, nevertheless, given changes in the environmental profile of the United States and other developed countries, it is important that we understand their effects in bone and cartilage. Research in this area will identify strategies that may be used to help prevent musculoskeletal diseases due to toxicant exposure. 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Edward</creatorcontrib><title>Environmental agents affect skeletal growth and development</title><title>Birth defects research. Part C. Embryo today</title><addtitle>Birth Defects Research Part C: Embryo Today: Reviews</addtitle><description>In this treatise we will examine complexities in the development and function of cells of the musculoskeletal system. Specifically, the role of chondrocytes and their ontogeny and osteoblasts and their ontogeny will be discussed as they regulate cartilage and bone formation. This background information will provide the foundation for evaluating the effects of environmental toxicants on skeletal development. A number of agents such as heavy metals (i.e. lead) and polycyclic aromatic hydrocarbons (i.e. pesticides and cigarette smoke) interact with cells of the skeletal system and adversely affect development. These agents have not been of major research interest, nevertheless, given changes in the environmental profile of the United States and other developed countries, it is important that we understand their effects in bone and cartilage. Research in this area will identify strategies that may be used to help prevent musculoskeletal diseases due to toxicant exposure. 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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Bone Development - drug effects Chondrocytes - cytology Chondrocytes - drug effects Chondrogenesis - drug effects Environmental Pollutants - toxicity Humans Lead Poisoning - complications Lead Poisoning - pathology Metals, Heavy - toxicity Osteoarthritis - etiology Osteoblasts - cytology Osteoblasts - drug effects Osteogenesis - drug effects Polycyclic Aromatic Hydrocarbons - toxicity Receptors, Aryl Hydrocarbon - drug effects Receptors, Aryl Hydrocarbon - metabolism |
| title | Environmental agents affect skeletal growth and development |
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