Developmental toxicity assessment of d,l-Methylphenidate and d-Methylphenidate in rats and rabbits

BACKGROUND: Previous investigations reported no teratogenicity for methylphenidate (MPH). These studies investigated potential teratogenicity of d‐MPH and d,l‐MPH as commitments to the FDA. METHODS: Rabbits received 15, 50, 150 mg/kg/day (mkd) d‐MPH or 20, 60, 200, 300 mkd d,l‐MPH on gestation days...

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Veröffentlicht in:	Birth defects research. Part B. Developmental and reproductive toxicology 2008-10, Vol.83 (5), p.489-501
Hauptverfasser:	Beckman, David A., Schneider, Marilynn, Youreneff, Maureen, Tse, Francis L.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - etiology Administration, Oral Animals Body Weight - drug effects Central Nervous System Stimulants - chemistry Central Nervous System Stimulants - toxicity developmental toxicity Dose-Response Relationship, Drug Eating - drug effects embryo/fetal development Embryonic Development - drug effects Female Hindlimb - drug effects Hindlimb - embryology Hindlimb - pathology Male Methylphenidate Methylphenidate - chemistry Methylphenidate - toxicity rabbit Rabbits rat Rats Rats, Wistar Respiration - drug effects Salivation - drug effects Spinal Dysraphism - embryology Spinal Dysraphism - pathology teratogen
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