G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning

The primary cilium is critical in sonic hedgehog (Shh)‐dependent ventral patterning of the vertebrate neural tube. Most mutants that cause disruption of the cilium result in decreased Shh signaling in the neural tube. In contrast, mutations in the intraflagellar complex A (IFT‐A) and the tubby famil...

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