Trichloroethylene and dichloroethylene: A critical review of teratogenicity
Trichloroethylene (TCE) and dichloroethylene (DCE) are high‐volume industrial chemicals frequently found as contaminants in public drinking water supplies. The developmental toxicity of both chemicals has been evaluated in laboratory and epidemiologic studies. It has been suggested that TCE and DCE...
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| Veröffentlicht in: | Birth defects research. A Clinical and molecular teratology 2005-12, Vol.73 (12), p.931-955 |
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| container_issue | 12 |
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| container_title | Birth defects research. A Clinical and molecular teratology |
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| creator | Hardin, Bryan D. Kelman, Bruce J. Brent, Robert L. |
| description | Trichloroethylene (TCE) and dichloroethylene (DCE) are high‐volume industrial chemicals frequently found as contaminants in public drinking water supplies. The developmental toxicity of both chemicals has been evaluated in laboratory and epidemiologic studies. It has been suggested that TCE and DCE are specific cardiac teratogens and that drinking water contaminated with them increases the risk of congenital heart defects in exposed human populations. In contrast, other laboratory and epidemiologic studies do not find an increase in developmental effects, either in general or specifically affecting the heart. This laboratory and epidemiologic base was reviewed to evaluate the strengths and weaknesses of the conflicting published reports. We conclude that the weight of experimental and epidemiologic evidence does not support the hypothesis that TCE or DCE is a selective developmental toxicant in general or a cardiac teratogen specifically. Birth Defects Research (Part A), 2005. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/bdra.20192 |
| format | Article |
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The developmental toxicity of both chemicals has been evaluated in laboratory and epidemiologic studies. It has been suggested that TCE and DCE are specific cardiac teratogens and that drinking water contaminated with them increases the risk of congenital heart defects in exposed human populations. In contrast, other laboratory and epidemiologic studies do not find an increase in developmental effects, either in general or specifically affecting the heart. This laboratory and epidemiologic base was reviewed to evaluate the strengths and weaknesses of the conflicting published reports. We conclude that the weight of experimental and epidemiologic evidence does not support the hypothesis that TCE or DCE is a selective developmental toxicant in general or a cardiac teratogen specifically. 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Obstetrics ; Humans ; Medical sciences ; Pregnancy ; Pregnancy. Fetus. Placenta ; Solvents ; Solvents - toxicity ; spontaneous abortion ; Teratogens - classification ; Teratogens - toxicity ; Teratology. Teratogens ; Toxicology ; trichloroethylene ; Trichloroethylene - classification ; Trichloroethylene - toxicity ; Water Pollutants, Chemical - toxicity</subject><ispartof>Birth defects research. 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A Clinical and molecular teratology</title><addtitle>Birth Defects Research Part A: Clinical and Molecular Teratology</addtitle><description>Trichloroethylene (TCE) and dichloroethylene (DCE) are high‐volume industrial chemicals frequently found as contaminants in public drinking water supplies. The developmental toxicity of both chemicals has been evaluated in laboratory and epidemiologic studies. It has been suggested that TCE and DCE are specific cardiac teratogens and that drinking water contaminated with them increases the risk of congenital heart defects in exposed human populations. In contrast, other laboratory and epidemiologic studies do not find an increase in developmental effects, either in general or specifically affecting the heart. This laboratory and epidemiologic base was reviewed to evaluate the strengths and weaknesses of the conflicting published reports. We conclude that the weight of experimental and epidemiologic evidence does not support the hypothesis that TCE or DCE is a selective developmental toxicant in general or a cardiac teratogen specifically. Birth Defects Research (Part A), 2005. © 2005 Wiley‐Liss, Inc.</description><subject>Abnormalities, Drug-Induced - etiology</subject><subject>Adult</subject><subject>Animals</subject><subject>Animals, Laboratory</subject><subject>Biological and medical sciences</subject><subject>birth weight</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>congenital heart disease</subject><subject>dichloroethylene</subject><subject>Dichloroethylenes - classification</subject><subject>Dichloroethylenes - toxicity</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>environmental exposure</subject><subject>Environmental Exposure - adverse effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Solvents</subject><subject>Solvents - toxicity</subject><subject>spontaneous abortion</subject><subject>Teratogens - classification</subject><subject>Teratogens - toxicity</subject><subject>Teratology. Teratogens</subject><subject>Toxicology</subject><subject>trichloroethylene</subject><subject>Trichloroethylene - classification</subject><subject>Trichloroethylene - toxicity</subject><subject>Water Pollutants, Chemical - toxicity</subject><issn>1542-0752</issn><issn>1542-0760</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90M9LwzAUB_AgipvTi3-A9OJF6MzvtN7mdFMcCjIRvIQ0TVy0a0danf3v7ezcwIOnPMLnvcf7AnCMYB9BiM-T1Ks-hijGO6CLGMUhFBzubmqGO-CgLN8aS4QQ-6CDOKEYi6gL7qbe6VlW-MJUszozuQlUngbpn8-LYBBo7yqnVRZ48-nMMihsUBmvquLV5E67qj4Ee1ZlpTlavz3wNLqeDm_CycP4djiYhJrEDIciSniClaCxUTRiKrKEKYEYjwWJtTY05ZZBTZEVEdY45gTblFKNYsgtIpr0wFk7V_uiLL2xcuHdXPlaIihXichVIvInkQaftHjxkcxNuqXrCBpwugaqbK6zXuXalVsnKCaY8Mah1i1dZup_VsrLq8fB7_Kw7XFlZb42Pcq_Sy6IYPL5fixf8IhPJ0Mmx-QbhhyHiA</recordid><startdate>200512</startdate><enddate>200512</enddate><creator>Hardin, Bryan D.</creator><creator>Kelman, Bruce J.</creator><creator>Brent, Robert L.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200512</creationdate><title>Trichloroethylene and dichloroethylene: A critical review of teratogenicity</title><author>Hardin, Bryan D. ; Kelman, Bruce J. ; Brent, Robert L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3952-78b6b2a749ea485a8f35a71569739cce4d6f50c41f782c29632fd44c1906f13c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Abnormalities, Drug-Induced - etiology</topic><topic>Adult</topic><topic>Animals</topic><topic>Animals, Laboratory</topic><topic>Biological and medical sciences</topic><topic>birth weight</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>congenital heart disease</topic><topic>dichloroethylene</topic><topic>Dichloroethylenes - classification</topic><topic>Dichloroethylenes - toxicity</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>environmental exposure</topic><topic>Environmental Exposure - adverse effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Solvents</topic><topic>Solvents - toxicity</topic><topic>spontaneous abortion</topic><topic>Teratogens - classification</topic><topic>Teratogens - toxicity</topic><topic>Teratology. Teratogens</topic><topic>Toxicology</topic><topic>trichloroethylene</topic><topic>Trichloroethylene - classification</topic><topic>Trichloroethylene - toxicity</topic><topic>Water Pollutants, Chemical - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hardin, Bryan D.</creatorcontrib><creatorcontrib>Kelman, Bruce J.</creatorcontrib><creatorcontrib>Brent, Robert L.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Birth defects research. 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The developmental toxicity of both chemicals has been evaluated in laboratory and epidemiologic studies. It has been suggested that TCE and DCE are specific cardiac teratogens and that drinking water contaminated with them increases the risk of congenital heart defects in exposed human populations. In contrast, other laboratory and epidemiologic studies do not find an increase in developmental effects, either in general or specifically affecting the heart. This laboratory and epidemiologic base was reviewed to evaluate the strengths and weaknesses of the conflicting published reports. We conclude that the weight of experimental and epidemiologic evidence does not support the hypothesis that TCE or DCE is a selective developmental toxicant in general or a cardiac teratogen specifically. 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| ispartof | Birth defects research. A Clinical and molecular teratology, 2005-12, Vol.73 (12), p.931-955 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Abnormalities, Drug-Induced - etiology Adult Animals Animals, Laboratory Biological and medical sciences birth weight Chemical and industrial products toxicology. Toxic occupational diseases congenital heart disease dichloroethylene Dichloroethylenes - classification Dichloroethylenes - toxicity Diseases of mother, fetus and pregnancy Embryology: invertebrates and vertebrates. Teratology environmental exposure Environmental Exposure - adverse effects Female Fundamental and applied biological sciences. Psychology Gynecology. Andrology. Obstetrics Humans Medical sciences Pregnancy Pregnancy. Fetus. Placenta Solvents Solvents - toxicity spontaneous abortion Teratogens - classification Teratogens - toxicity Teratology. Teratogens Toxicology trichloroethylene Trichloroethylene - classification Trichloroethylene - toxicity Water Pollutants, Chemical - toxicity |
| title | Trichloroethylene and dichloroethylene: A critical review of teratogenicity |
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