Genetic susceptibility to thalidomide embryopathy in humans: Study of candidate development genes

Thalidomide is a drug used worldwide for several indications, but the molecular mechanisms of its teratogenic property are not fully understood. Studies in animal models suggest the oxidative stress, the inhibition of angiogenesis, and the binding to E3‐ubiquitin ligase complex as mechanisms by whic...

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Veröffentlicht in:	Birth defects research 2018-03, Vol.110 (5), p.456-461
Hauptverfasser:	Gomes, Julia do Amaral, Kowalski, Thayne Woycinck, Fraga, Lucas Rosa, Tovo‐Rodrigues, Luciana, Sanseverino, Maria Teresa Vieira, Schuler‐Faccini, Lavínia, Vianna, Fernanda Sales Luiz
Format:	Artikel
Sprache:	eng
Schlagworte:	birth defects genetics limb reduction defects polymorphism teratogenesis
Online-Zugang:	Volltext
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