The role of organic anion-transporting polypeptides and formulation in the clearance and distribution of a novel Na v 1.7 channel blocker

PF-06456384 is an extremely potent and selective blocker of the Na 1.7 sodium channel designed as a potential intravenous (i.v.) analgesic targeting high potency and rapid clearance to minimize the potential for residual effects following the end of infusion. In our previous experience targeting ora...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biopharmaceutics & drug disposition 2018-09, Vol.39 (8), p.388-393
Hauptverfasser:	Pike, Andy, Flanagan, Neil J, Storer, R Ian, Swain, Nigel A, Tseng, Elaine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Interactions Excipients - pharmacokinetics Male NAV1.7 Voltage-Gated Sodium Channel Organic Anion Transporters - metabolism Piperidines - pharmacokinetics Polyethylene Glycols - pharmacokinetics Pyridines - pharmacokinetics Rats, Wistar Stearic Acids - pharmacokinetics Thiadiazoles - pharmacokinetics Voltage-Gated Sodium Channel Blockers - pharmacokinetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!