Rh(III)‐Catalyzed Sequential ortho ‐C‐H Bond Annulation and Desulfonylation of 3‐Aryl‐2 H ‐benzo[ e ][1,2,4]thiadiazine‐1,1‐dioxides: Access to 1‐Aminoisoquinolines

Rh(III)‐Catalyzed Sequential ortho ‐C‐H Bond Annulation and Desulfonylation of 3‐Aryl‐2 H ‐benzo[ e ][1,2,4]thiadiazine‐1,1‐dioxides: Access to 1‐Aminoisoquinolines

An efficient Rh(III)‐catalyzed C−H functionalization of 3‐aryl‐2 H ‐benzo[ e ][1,2,4]thiadiazine‐1,1‐dioxides with diaryl and dialkyl alkynes has been developed for the first time to the synthesis of 1‐aminoisoquinoline derivatives in a single step. This method involves through the formation of one...

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Veröffentlicht in:Chemistry, an Asian journal an Asian journal, 2024-12, Vol.19 (23)
Hauptverfasser: Ajay, Chidrawar, Balasubramanian, Sridhar, Subba Reddy, Basi V.
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Subba Reddy, Basi V.
description An efficient Rh(III)‐catalyzed C−H functionalization of 3‐aryl‐2 H ‐benzo[ e ][1,2,4]thiadiazine‐1,1‐dioxides with diaryl and dialkyl alkynes has been developed for the first time to the synthesis of 1‐aminoisoquinoline derivatives in a single step. This method involves through the formation of one C−C bond and one C−N bond followed by desulfonylation to generate a novel series of isoquinolines in good to excellent yields. This is a direct method to produce pharmaceutically more relevant scaffolds with a high functional diversity.
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title Rh(III)‐Catalyzed Sequential ortho ‐C‐H Bond Annulation and Desulfonylation of 3‐Aryl‐2 H ‐benzo[ e ][1,2,4]thiadiazine‐1,1‐dioxides: Access to 1‐Aminoisoquinolines
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