One‐Step Synthesis of the 1‐Azaspiro[5.5]undecane Skeleton Characteristic of Histrionicotoxin Alkaloids from Linear Substrates via Hg(OTf)2‐Catalyzed Cycloisomerization

Histrionicotoxin (HTX) alkaloids isolated from the poison arrow frogs possess a unique structure characterized by a 1‐azaspiro[5.5]undecane skeleton common to the HTX family. The unique molecular architecture of HTXs and the interest as potential target drugs have prompted synthetic chemists to prom...

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Veröffentlicht in:	Chemistry, an Asian journal an Asian journal, 2021-07, Vol.16 (14), p.1882-1886
Hauptverfasser:	Matsumura, Kunihiro, Nishikawa, Keisuke, Yoshida, Hiroaki, Niwa, Toshiki, Fushii, Yuichiro, Doe, Matsumi, Morimoto, Yoshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids cyclization diastereoselectivity spiro compounds total synthesis
Online-Zugang:	Volltext
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