Infliximab treatment shifts the balance between stimulatory and inhibitory Fcγ receptor type II isoforms on neutrophils in patients with rheumatoid arthritis

Objective Human neutrophils express both activating and inhibitory Fcγ receptors (FcγR), and their relative expression determines the inflammatory response to immune complexes. Tumor necrosis factor α (TNFα) up‐regulates the expression of stimulatory FcγRIIa on neutrophils in vitro, and amplifies im...

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Veröffentlicht in:	Arthritis and rheumatism 2008-02, Vol.58 (2), p.384-388
Hauptverfasser:	Belostocki, Kristina, Pricop, Luminita, Redecha, Patricia B., Aydin, Ani, Leff, Linda, Harrison, Melanie J., Salmon, Jane E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Diseases of the osteoarticular system Immunomodulators Inflammatory joint diseases Medical sciences Pharmacology. Drug treatments
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