A multicenter, prospective, randomized, double‐blind, placebo‐controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary fibrosis in scleroderma

Objective The lack of randomized controlled trials (RCTs) in pulmonary fibrosis in systemic sclerosis (SSc) has hampered an evidence‐based approach to treatment. This RCT was undertaken to investigate the effects of intravenous (IV) cyclophosphamide (CYC) followed by azathioprine (AZA) treatment in...

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Veröffentlicht in:	Arthritis and rheumatism 2006-12, Vol.54 (12), p.3962-3970
Hauptverfasser:	Hoyles, Rachel K., Ellis, Ross W., Wellsbury, Jessica, Lees, Belinda, Newlands, Pauline, Goh, Nicole S. L., Roberts, Christopher, Desai, Sujal, Herrick, Ariane L., McHugh, Neil J., Foley, Noeleen M., Pearson, Stanley B., Emery, Paul, Veale, Douglas J., Denton, Christopher P., Wells, Athol U., Black, Carol M., du Bois, Roland M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent Adult Aged Azathioprine - therapeutic use Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Cyclophosphamide - therapeutic use Double-Blind Method Drug Therapy, Combination Female Glucocorticoids - therapeutic use Humans Immunosuppressive Agents - therapeutic use Injections, Intravenous Male Medical sciences Middle Aged Pharmacology. Drug treatments Pneumology Prednisolone - therapeutic use Prospective Studies Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - etiology Pulmonary Fibrosis - physiopathology Respiratory Function Tests Respiratory system : syndromes and miscellaneous diseases Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Scleroderma, Systemic - complications Scleroderma, Systemic - drug therapy Scleroderma, Systemic - physiopathology Treatment Outcome
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