Novel autoantibodies directed against the common tertiary configuration of transfer RNA in a patient with interstitial lung disease

Objective. To identify and characterize a novel autoantibody, anti‐WS, that binds total transfer RNA (tRNA). Methods. Serum from patient WS, who had polyarthritis, Sjögren's syndrome, Raynaud's phenomenon, and interstitial pulmonary fibrosis, was used in this study. Characteristics of anti...

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Veröffentlicht in:	Arthritis and rheumatism 1996-08, Vol.39 (8), p.1308-1312
Hauptverfasser:	Matsumura, Mami, Ohosone, Yasuo, Miyachi, Kiyomitsu, Akizuki, Masashi, Matsuoka, Yasuo, Irimajiri, Shoichiro, Shimizu, Mikio, Mimori, Tsuneyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoantibodies - analysis Biological and medical sciences Escherichia coli - chemistry Female Fluorescent Antibody Technique, Indirect Gene Deletion Humans Lung Diseases, Interstitial - immunology Medical sciences Middle Aged Mutagenesis - immunology Phosphorus Radioisotopes Precipitin Tests Protein Conformation Protein Structure, Tertiary RNA, Transfer - chemistry RNA, Transfer - genetics RNA, Transfer - immunology RNA, Transfer, Asp - chemistry RNA, Transfer, Asp - genetics RNA, Transfer, Asp - immunology RNA, Transfer, His - chemistry RNA, Transfer, His - genetics RNA, Transfer, His - immunology RNA, Transfer, Ser - chemistry RNA, Transfer, Ser - genetics RNA, Transfer, Ser - immunology RNA, Transfer, Trp - chemistry RNA, Transfer, Trp - genetics RNA, Transfer, Trp - immunology RNA, Transfer, Val - chemistry RNA, Transfer, Val - genetics RNA, Transfer, Val - immunology Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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