Frentizole therapy in systemic lupus erythematosus

Seven corticosteroid dependent patients with active systemic lupus erythematosus (SLE) were given frentizole in order to assess its effect on their clinical manifestations. Three patients exhibited slight clinical improvement, 2 patients did not change, and 2 deteriorated. Five of the 7 patients dev...

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Veröffentlicht in:	Arthritis and rheumatism 1980-12, Vol.23 (12), p.1376-1380
Hauptverfasser:	Sabharwal, Umesh K., Vaughan, John H., Kaplan, Roy A., Robinson, Charles A., Curd, John G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Benzothiazoles Chemical and Drug Induced Liver Injury - pathology Clinical Trials as Topic Female Follow-Up Studies Humans Immunosuppressive Agents Kidney - drug effects Liver - drug effects Liver - pathology Liver Cirrhosis - chemically induced Lupus Erythematosus, Systemic - diagnosis Lupus Erythematosus, Systemic - drug therapy Middle Aged Nephritis - chemically induced Phenylurea Compounds - adverse effects Phenylurea Compounds - therapeutic use Thiazoles - adverse effects Thiazoles - therapeutic use
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Beschreibung
Zusammenfassung:	Seven corticosteroid dependent patients with active systemic lupus erythematosus (SLE) were given frentizole in order to assess its effect on their clinical manifestations. Three patients exhibited slight clinical improvement, 2 patients did not change, and 2 deteriorated. Five of the 7 patients developed subclinical and reversible liver damage related to frentizole. This study, although preliminary and uncontrolled, suggests that frentizole is of limited value in the management of patients with SLE.
ISSN:	0004-3591 1529-0131
DOI:	10.1002/art.1780231208