Virologic Studies on Rheumatoid Arthritis
A search for viral agents associated with rheumatoid arthritis was made using cell lines derived from 64 joint fluids and 41 tissue biopsies (including 29 synovia, 10 rheumatoid nodules, and 2 rheumatoid cartilage). Virus recovery was attempted using a variety of techniques including cell fusion. No...
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| Veröffentlicht in: | Arthritis and rheumatism 1973-07, Vol.16 (4), p.446-454 |
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| container_issue | 4 |
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| container_title | Arthritis and rheumatism |
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| creator | Wilkes, R. Michael Simsarian, James P. Hopps, Hope E. Roth, Henry Decker, John L. Aptekar, Robert G. Meyer, Harry M. |
| description | A search for viral agents associated with rheumatoid arthritis was made using cell lines derived from 64 joint fluids and 41 tissue biopsies (including 29 synovia, 10 rheumatoid nodules, and 2 rheumatoid cartilage). Virus recovery was attempted using a variety of techniques including cell fusion. No viruses were isolated nor were significant patterns of antiviral antibodies found in sera from patients with arthritis. Using seven different viruses, including rubella and Newcastle disease virus, the viral susceptibility of cell lines derived from rheumatoid and nonrheumatoid patients was compared; there was no evidence of significant differences. |
| doi_str_mv | 10.1002/art.1780160403 |
| format | Article |
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Michael ; Simsarian, James P. ; Hopps, Hope E. ; Roth, Henry ; Decker, John L. ; Aptekar, Robert G. ; Meyer, Harry M.</creator><creatorcontrib>Wilkes, R. Michael ; Simsarian, James P. ; Hopps, Hope E. ; Roth, Henry ; Decker, John L. ; Aptekar, Robert G. ; Meyer, Harry M.</creatorcontrib><description>A search for viral agents associated with rheumatoid arthritis was made using cell lines derived from 64 joint fluids and 41 tissue biopsies (including 29 synovia, 10 rheumatoid nodules, and 2 rheumatoid cartilage). Virus recovery was attempted using a variety of techniques including cell fusion. No viruses were isolated nor were significant patterns of antiviral antibodies found in sera from patients with arthritis. Using seven different viruses, including rubella and Newcastle disease virus, the viral susceptibility of cell lines derived from rheumatoid and nonrheumatoid patients was compared; there was no evidence of significant differences.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780160403</identifier><identifier>PMID: 4722429</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Antibodies, Viral - analysis ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - microbiology ; Biopsy ; Cartilage, Articular - microbiology ; Cell Line ; Cytopathogenic Effect, Viral ; Cytotoxicity Tests, Immunologic ; HeLa Cells ; Hemagglutination Inhibition Tests ; Humans ; Interferons - analysis ; Newcastle disease virus - immunology ; Rubella virus - immunology ; Synovial Fluid - microbiology ; Virus Diseases</subject><ispartof>Arthritis and rheumatism, 1973-07, Vol.16 (4), p.446-454</ispartof><rights>Copyright © 1973 American College of Rheumatology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3803-4fdf510c929129aa2d9acf3355e44b0f8e83b17c8f638085bebd175bd1073b8b3</citedby><cites>FETCH-LOGICAL-c3803-4fdf510c929129aa2d9acf3355e44b0f8e83b17c8f638085bebd175bd1073b8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.1780160403$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.1780160403$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4722429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wilkes, R. Michael</creatorcontrib><creatorcontrib>Simsarian, James P.</creatorcontrib><creatorcontrib>Hopps, Hope E.</creatorcontrib><creatorcontrib>Roth, Henry</creatorcontrib><creatorcontrib>Decker, John L.</creatorcontrib><creatorcontrib>Aptekar, Robert G.</creatorcontrib><creatorcontrib>Meyer, Harry M.</creatorcontrib><title>Virologic Studies on Rheumatoid Arthritis</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>A search for viral agents associated with rheumatoid arthritis was made using cell lines derived from 64 joint fluids and 41 tissue biopsies (including 29 synovia, 10 rheumatoid nodules, and 2 rheumatoid cartilage). Virus recovery was attempted using a variety of techniques including cell fusion. No viruses were isolated nor were significant patterns of antiviral antibodies found in sera from patients with arthritis. Using seven different viruses, including rubella and Newcastle disease virus, the viral susceptibility of cell lines derived from rheumatoid and nonrheumatoid patients was compared; there was no evidence of significant differences.</description><subject>Antibodies, Viral - analysis</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - microbiology</subject><subject>Biopsy</subject><subject>Cartilage, Articular - microbiology</subject><subject>Cell Line</subject><subject>Cytopathogenic Effect, Viral</subject><subject>Cytotoxicity Tests, Immunologic</subject><subject>HeLa Cells</subject><subject>Hemagglutination Inhibition Tests</subject><subject>Humans</subject><subject>Interferons - analysis</subject><subject>Newcastle disease virus - immunology</subject><subject>Rubella virus - immunology</subject><subject>Synovial Fluid - microbiology</subject><subject>Virus Diseases</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFj0tLw0AUhQdRaq1u3QnZuki8dx7NzLIUX1AQanUbZpIZO5KYMpMg_fdGUtSdm3u4nAd8hFwiZAhAb3ToMswl4Bw4sCMyRUFVCsjwmEwBgKdMKDwlZzG-Dy9lgk3IhOeUcqqm5PrVh7Zu33yZPHd95W1M2o9kvbV9o7vWV8kidNvgOx_PyYnTdbQXB52Rl7vbzfIhXT3dPy4Xq7RkEljKXeUEQqmoQqq0ppXSpWNMCMu5ASetZAbzUrr5kJfCWFNhLoYDOTPSsBnJxt0ytDEG64pd8I0O-wKh-EYuBuTiF3koXI2FXW8aW_3ED4yDr0b_09d2_89asVhv_mx_AXSMYYE</recordid><startdate>197307</startdate><enddate>197307</enddate><creator>Wilkes, R. 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Michael</creatorcontrib><creatorcontrib>Simsarian, James P.</creatorcontrib><creatorcontrib>Hopps, Hope E.</creatorcontrib><creatorcontrib>Roth, Henry</creatorcontrib><creatorcontrib>Decker, John L.</creatorcontrib><creatorcontrib>Aptekar, Robert G.</creatorcontrib><creatorcontrib>Meyer, Harry M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wilkes, R. Michael</au><au>Simsarian, James P.</au><au>Hopps, Hope E.</au><au>Roth, Henry</au><au>Decker, John L.</au><au>Aptekar, Robert G.</au><au>Meyer, Harry M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Virologic Studies on Rheumatoid Arthritis</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1973-07</date><risdate>1973</risdate><volume>16</volume><issue>4</issue><spage>446</spage><epage>454</epage><pages>446-454</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><abstract>A search for viral agents associated with rheumatoid arthritis was made using cell lines derived from 64 joint fluids and 41 tissue biopsies (including 29 synovia, 10 rheumatoid nodules, and 2 rheumatoid cartilage). Virus recovery was attempted using a variety of techniques including cell fusion. No viruses were isolated nor were significant patterns of antiviral antibodies found in sera from patients with arthritis. Using seven different viruses, including rubella and Newcastle disease virus, the viral susceptibility of cell lines derived from rheumatoid and nonrheumatoid patients was compared; there was no evidence of significant differences.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>4722429</pmid><doi>10.1002/art.1780160403</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Arthritis and rheumatism, 1973-07, Vol.16 (4), p.446-454 |
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| language | eng |
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| source | MEDLINE; Wiley Journals; Alma/SFX Local Collection |
| subjects | Antibodies, Viral - analysis Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - microbiology Biopsy Cartilage, Articular - microbiology Cell Line Cytopathogenic Effect, Viral Cytotoxicity Tests, Immunologic HeLa Cells Hemagglutination Inhibition Tests Humans Interferons - analysis Newcastle disease virus - immunology Rubella virus - immunology Synovial Fluid - microbiology Virus Diseases |
| title | Virologic Studies on Rheumatoid Arthritis |
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