Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated
Absorption of gold from injected sites occurs rapidly, reaching its peak in blood between 4 and 6 hours. In plasma, 95% of gold is bound to albumin. Three patients that were studied from the beginning of weekly therapy showed a progressive stepwise rise in plasma gold levels up to the sixth week. Ur...
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| Veröffentlicht in: | Arthritis and rheumatism 1972-07, Vol.15 (4), p.391-402 |
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| container_title | Arthritis and rheumatism |
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| creator | Mascarenhas, Bento R. Granda, Jose Luis Freyberg, Richard H. |
| description | Absorption of gold from injected sites occurs rapidly, reaching its peak in blood between 4 and 6 hours. In plasma, 95% of gold is bound to albumin. Three patients that were studied from the beginning of weekly therapy showed a progressive stepwise rise in plasma gold levels up to the sixth week. Urinary excretion was greatest during the first day postinjection while fecal excretion was greatest during the middle of the week. The blood levels, as well as excretion, varied from patient to patient. Patients on maintenance therapy excreted 39, 16, 12 and 10% of the injected dose in the first, second, third and fourth weeks postinjection, respectively. There were no significant differences in blood gold levels in patients who showed a good therapeutic response, no therapeutic benefit or toxicity. |
| doi_str_mv | 10.1002/art.1780150410 |
| format | Article |
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There were no significant differences in blood gold levels in patients who showed a good therapeutic response, no therapeutic benefit or toxicity.</description><identifier>ISSN: 0004-3591</identifier><identifier>EISSN: 1529-0131</identifier><identifier>DOI: 10.1002/art.1780150410</identifier><identifier>PMID: 5046469</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Arthritis, Rheumatoid - drug therapy ; Arthritis, Rheumatoid - metabolism ; Chromatography, Gel ; Electrophoresis, Paper ; Feces - analysis ; Glucose - metabolism ; Gold - adverse effects ; Gold - blood ; Gold - metabolism ; Gold - therapeutic use ; Gold - urine ; Gold Isotopes ; Humans ; In Vitro Techniques ; Methods ; Protein Binding ; Spectrophotometry ; Thiomalates - metabolism ; Time Factors</subject><ispartof>Arthritis and rheumatism, 1972-07, Vol.15 (4), p.391-402</ispartof><rights>Copyright © 1972 American College of Rheumatology</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3400-8e8b268d1946548c8781712fd1d4637cdb9ccd9abb735b0e7bca537f16a72ff3</citedby><cites>FETCH-LOGICAL-c3400-8e8b268d1946548c8781712fd1d4637cdb9ccd9abb735b0e7bca537f16a72ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.1780150410$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.1780150410$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5046469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mascarenhas, Bento R.</creatorcontrib><creatorcontrib>Granda, Jose Luis</creatorcontrib><creatorcontrib>Freyberg, Richard H.</creatorcontrib><title>Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated</title><title>Arthritis and rheumatism</title><addtitle>Arthritis Rheum</addtitle><description>Absorption of gold from injected sites occurs rapidly, reaching its peak in blood between 4 and 6 hours. In plasma, 95% of gold is bound to albumin. Three patients that were studied from the beginning of weekly therapy showed a progressive stepwise rise in plasma gold levels up to the sixth week. Urinary excretion was greatest during the first day postinjection while fecal excretion was greatest during the middle of the week. The blood levels, as well as excretion, varied from patient to patient. Patients on maintenance therapy excreted 39, 16, 12 and 10% of the injected dose in the first, second, third and fourth weeks postinjection, respectively. There were no significant differences in blood gold levels in patients who showed a good therapeutic response, no therapeutic benefit or toxicity.</description><subject>Arthritis, Rheumatoid - drug therapy</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Chromatography, Gel</subject><subject>Electrophoresis, Paper</subject><subject>Feces - analysis</subject><subject>Glucose - metabolism</subject><subject>Gold - adverse effects</subject><subject>Gold - blood</subject><subject>Gold - metabolism</subject><subject>Gold - therapeutic use</subject><subject>Gold - urine</subject><subject>Gold Isotopes</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Methods</subject><subject>Protein Binding</subject><subject>Spectrophotometry</subject><subject>Thiomalates - metabolism</subject><subject>Time Factors</subject><issn>0004-3591</issn><issn>1529-0131</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1972</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1Kw0AUhQdRaq1u3Ql5gcS5mUlmsixFq1AQpPswf2lH8sfM1NKdD-ET-iSmpKg7V5fL-c65l4PQLeAEME7vhQsJMI4hwxTwGZpClhYxBgLnaIoxpjHJCrhEV96_DWtKMjJBkwHOaV5MkVx2tY4aE4TsauubyLZRL4I1bfDR3oZt5LZm14jQWR0Nt7bOBuuj4IwIRo_E5hihuqbvdq32Xx-fztj23fhgN0foGl1Uovbm5jRnaP34sF48xauX5fNivooVoRjH3HCZ5lxDQfOMcsUZBwZppUHTnDClZaGULoSUjGQSGyaVyAirIBcsrSoyQ8kYq1znvTNV2TvbCHcoAZfHqsrh_fK3qsFwNxr6nWyM_sFP3Qx6Mep7W5vDP2nl_HX9J_sbdQB4yQ</recordid><startdate>197207</startdate><enddate>197207</enddate><creator>Mascarenhas, Bento R.</creator><creator>Granda, Jose Luis</creator><creator>Freyberg, Richard H.</creator><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197207</creationdate><title>Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated</title><author>Mascarenhas, Bento R. ; Granda, Jose Luis ; Freyberg, Richard H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3400-8e8b268d1946548c8781712fd1d4637cdb9ccd9abb735b0e7bca537f16a72ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1972</creationdate><topic>Arthritis, Rheumatoid - drug therapy</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Chromatography, Gel</topic><topic>Electrophoresis, Paper</topic><topic>Feces - analysis</topic><topic>Glucose - metabolism</topic><topic>Gold - adverse effects</topic><topic>Gold - blood</topic><topic>Gold - metabolism</topic><topic>Gold - therapeutic use</topic><topic>Gold - urine</topic><topic>Gold Isotopes</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Methods</topic><topic>Protein Binding</topic><topic>Spectrophotometry</topic><topic>Thiomalates - metabolism</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Mascarenhas, Bento R.</creatorcontrib><creatorcontrib>Granda, Jose Luis</creatorcontrib><creatorcontrib>Freyberg, Richard H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Arthritis and rheumatism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mascarenhas, Bento R.</au><au>Granda, Jose Luis</au><au>Freyberg, Richard H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated</atitle><jtitle>Arthritis and rheumatism</jtitle><addtitle>Arthritis Rheum</addtitle><date>1972-07</date><risdate>1972</risdate><volume>15</volume><issue>4</issue><spage>391</spage><epage>402</epage><pages>391-402</pages><issn>0004-3591</issn><eissn>1529-0131</eissn><abstract>Absorption of gold from injected sites occurs rapidly, reaching its peak in blood between 4 and 6 hours. In plasma, 95% of gold is bound to albumin. Three patients that were studied from the beginning of weekly therapy showed a progressive stepwise rise in plasma gold levels up to the sixth week. Urinary excretion was greatest during the first day postinjection while fecal excretion was greatest during the middle of the week. The blood levels, as well as excretion, varied from patient to patient. Patients on maintenance therapy excreted 39, 16, 12 and 10% of the injected dose in the first, second, third and fourth weeks postinjection, respectively. There were no significant differences in blood gold levels in patients who showed a good therapeutic response, no therapeutic benefit or toxicity.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><pmid>5046469</pmid><doi>10.1002/art.1780150410</doi><tpages>12</tpages></addata></record> |
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| ispartof | Arthritis and rheumatism, 1972-07, Vol.15 (4), p.391-402 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals; Alma/SFX Local Collection |
| subjects | Arthritis, Rheumatoid - drug therapy Arthritis, Rheumatoid - metabolism Chromatography, Gel Electrophoresis, Paper Feces - analysis Glucose - metabolism Gold - adverse effects Gold - blood Gold - metabolism Gold - therapeutic use Gold - urine Gold Isotopes Humans In Vitro Techniques Methods Protein Binding Spectrophotometry Thiomalates - metabolism Time Factors |
| title | Gold metabolism in patients with rheumatoid arthritis treated with gold compounds—reinvestigated |
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