Sex hormones, bone changes and osteoarthritis in DBA/2JN mice

Several possible mechanisms by which sex hormones may influence development of osteoarthritis in mice have been investigated. No relationship existed between the joint disease and mineral content of the bone. A sexual dimorphism in femur length is described for the first time. Strain differences in the effect of sex hormones on the joints of STR/1N and other strains of mice cannot be accounted for by a proposed “dyschondrogenesis.” Esseva investigate plure possible mechanismos per que hormones sexual pote influentiar le disveloppamento de osteoarthritis in muses. Nulle relation esseva trovate le inter le morbo articular e le contento mineral del osso. Un dimorphismo sexual in le longor del femore es describite pro le prime vice. Differentias inter muses STR/1N e altere lineas con respecto al effecto del hormones de sexo super le articulationes non pote esser explicate per un proponite “dyschondrogenese.”