Synthesis and Pharmacological Evaluation of Some 3‐(4‐Methylphenyl)‐2‐substituted amino‐3 H ‐quinazolin‐4‐ones as Analgesic and Anti‐inflammatory Agents

Synthesis and Pharmacological Evaluation of Some 3‐(4‐Methylphenyl)‐2‐substituted amino‐3 H ‐quinazolin‐4‐ones as Analgesic and Anti‐inflammatory Agents

A variety of 3‐(4‐methyl phenyl)‐2‐substituted amino‐3 H ‐quinazolin‐4‐ones were synthesized by reacting the amino group of 2‐hydrazino‐3‐(4‐methyl phenyl)‐3 H ‐quinazolin‐4‐one with a variety of aldehydes and ketones. The starting material 2‐hydrazino‐3‐(4‐methyl phenyl)‐3 H ‐quinazolin‐4‐one was s...

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Veröffentlicht in:Archiv der Pharmazie (Weinheim) 2007-01, Vol.340 (1), p.41-46
Hauptverfasser: Alagarsamy, Veerachamy, Shankar, Durairaj, Murugan, Muthuvel, Siddiqui, Anees Ahmed, Rajesh, Ramadoss
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container_title Archiv der Pharmazie (Weinheim)
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creator Alagarsamy, Veerachamy
Shankar, Durairaj
Murugan, Muthuvel
Siddiqui, Anees Ahmed
Rajesh, Ramadoss
description A variety of 3‐(4‐methyl phenyl)‐2‐substituted amino‐3 H ‐quinazolin‐4‐ones were synthesized by reacting the amino group of 2‐hydrazino‐3‐(4‐methyl phenyl)‐3 H ‐quinazolin‐4‐one with a variety of aldehydes and ketones. The starting material 2‐hydrazino‐3‐(4‐methyl phenyl)‐3 H ‐quinazolin‐4‐one was synthesized from 4‐methyl aniline. The title compounds were investigated for analgesic, anti‐inflammatory, and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds A1 , A2 , and A3 showed more potent analgesic activity and the compound A3 showed more potent anti‐inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared to aspirin.
doi_str_mv 10.1002/ardp.200600189
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title Synthesis and Pharmacological Evaluation of Some 3‐(4‐Methylphenyl)‐2‐substituted amino‐3 H ‐quinazolin‐4‐ones as Analgesic and Anti‐inflammatory Agents
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