Nucleosides and Nucleotides, Part 144 Synthesis and Antiviral Activity of 5-Substituted (2′S)-2′-Deoxy-2′-C-Methylcytidines and -uridines[1]

Synthesis of several 5‐substituted (2′S)‐2′‐deoxy‐2′‐C‐methylcytidines (8) and ‐uridines (6, 11) has been accomplished using radical deoxygenation of the 2′‐tert‐alcohols via their methyl oxalyl esters as a key reaction. Anti‐herpes simplex virus type‐1 and ‐2, and anti‐varicella‐zoster virus activi...

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Veröffentlicht in:	Archiv der Pharmazie (Weinheim) 1996, Vol.329 (2), p.66-72
Hauptverfasser:	Awano, Hirokazu, Shuto, Satoshi, Miyashita, Takanori, Ashida, Noriyuki, Machida, Haruhiko, Kira, Toshihiko, Shigeta, Shiro, Matsuda, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor activity antiviral activity branched-sugar nucleoside palladium-catalyzed cross-coupling radical deoxygenation
Online-Zugang:	Volltext
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