Effects of platelet‐derived growth factor‐AA and ‐BB on embryonic cardiac development

Several studies have shown that disruption of the normal expression patterns of platelet‐derived growth factor (PDGF) ligands and receptors during development results in gross cardiac defects and embryonic or neonatal death. However, little is known about the specific role that PDGF plays in the dif...

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Veröffentlicht in:	The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology Discoveries in molecular, cellular, and evolutionary biology, 2003-05, Vol.272A (1), p.424-433
Hauptverfasser:	Price, Robert L., Haley, Stephen T., Bullard, Tara A., Goldsmith, Edie C., Simpson, David G., Thielen, Thomas E., Yost, Michael J., Terracio, Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cardiac development Cell Differentiation - drug effects Cell Differentiation - physiology confocal microscopy electron microscopy Female Heart - drug effects Heart - embryology Heart Defects, Congenital - chemically induced Heart Defects, Congenital - metabolism Heart Defects, Congenital - physiopathology Mice Mice, Inbred C57BL Microscopy, Electron Muscle Cells - drug effects Muscle Cells - metabolism Muscle Cells - ultrastructure Myocardium - metabolism Myocardium - ultrastructure myofibrillogenesis Myofibrils - drug effects Myofibrils - metabolism Myofibrils - ultrastructure Platelet-Derived Growth Factor - metabolism Platelet-Derived Growth Factor - pharmacology platelet‐derived growth factor Proto-Oncogene Proteins c-sis Rats Rats, Sprague-Dawley Receptor, Platelet-Derived Growth Factor alpha - metabolism Receptor, Platelet-Derived Growth Factor beta - metabolism Sarcomeres - drug effects Sarcomeres - metabolism Sarcomeres - ultrastructure
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