Safety assessment of polymeric additives for food packaging: Hydrolysis of polymeric plasticizers by digestive fluids
The in vitro hydrolysis of poly(1,2‐propylene adipate) by digestive fluid liquids was studied to assess the safety of polymeric plasticizers that could migrate into food. A high extent of hydrolysis was obtained with freshly prepared intestinal fluid solutions. High performance size exclusion chroma...
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| Veröffentlicht in: | Journal of applied polymer science 2002-01, Vol.83 (5), p.956-966 |
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| container_title | Journal of applied polymer science |
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| creator | Hamdani, M. Thil, L. Gans, G. Feigenbaum, A. E. |
| description | The in vitro hydrolysis of poly(1,2‐propylene adipate) by digestive fluid liquids was studied to assess the safety of polymeric plasticizers that could migrate into food. A high extent of hydrolysis was obtained with freshly prepared intestinal fluid solutions. High performance size exclusion chromatography analysis indicated that the bulk plasticizer completely disappeared and that low molecular weight oligomers were formed within 4 h. Hydrolysis did not result in a significant conversion to the free monomers, like adipic acid, as was shown by gas‐phase chromatography. Measurements by NMR indicated that the cleavage selectively occurred at primary ester linkages. Fractionation of the hydrolysis products on silica gel gave six oligomeric fractions, which were recovered and analyzed. The absolute molecular weight of the plasticizers and the average molecular weight of the hydrolysis products were evaluated using proton NMR. Hydrolysis did not take place ( |
| doi_str_mv | 10.1002/app.2275 |
| format | Article |
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E.</creator><creatorcontrib>Hamdani, M. ; Thil, L. ; Gans, G. ; Feigenbaum, A. E.</creatorcontrib><description>The in vitro hydrolysis of poly(1,2‐propylene adipate) by digestive fluid liquids was studied to assess the safety of polymeric plasticizers that could migrate into food. A high extent of hydrolysis was obtained with freshly prepared intestinal fluid solutions. High performance size exclusion chromatography analysis indicated that the bulk plasticizer completely disappeared and that low molecular weight oligomers were formed within 4 h. Hydrolysis did not result in a significant conversion to the free monomers, like adipic acid, as was shown by gas‐phase chromatography. Measurements by NMR indicated that the cleavage selectively occurred at primary ester linkages. Fractionation of the hydrolysis products on silica gel gave six oligomeric fractions, which were recovered and analyzed. The absolute molecular weight of the plasticizers and the average molecular weight of the hydrolysis products were evaluated using proton NMR. Hydrolysis did not take place (<2%) under simulated gastric and saliva conditions. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 956–966, 2002</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.2275</identifier><identifier>CODEN: JAPNAB</identifier><language>eng</language><publisher>New York: Wiley Periodicals, Inc</publisher><subject>Applied sciences ; Compounding ingredients ; digestive fluid simulants ; Exact sciences and technology ; food packaging ; hydrolysis ; oligomers ; pancreatin ; Plasticizers ; Polymer industry, paints, wood ; polymeric plasticizer ; regulation ; Technology of polymers</subject><ispartof>Journal of applied polymer science, 2002-01, Vol.83 (5), p.956-966</ispartof><rights>Copyright © 2002 Wiley Periodicals, Inc.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3315-6fdd714df7503d7c02a9264c2b43a3fe3d72bae89ccc17d2dcb03a22305872f23</citedby><cites>FETCH-LOGICAL-c3315-6fdd714df7503d7c02a9264c2b43a3fe3d72bae89ccc17d2dcb03a22305872f23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.2275$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.2275$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14097296$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamdani, M.</creatorcontrib><creatorcontrib>Thil, L.</creatorcontrib><creatorcontrib>Gans, G.</creatorcontrib><creatorcontrib>Feigenbaum, A. E.</creatorcontrib><title>Safety assessment of polymeric additives for food packaging: Hydrolysis of polymeric plasticizers by digestive fluids</title><title>Journal of applied polymer science</title><addtitle>J. Appl. Polym. Sci</addtitle><description>The in vitro hydrolysis of poly(1,2‐propylene adipate) by digestive fluid liquids was studied to assess the safety of polymeric plasticizers that could migrate into food. A high extent of hydrolysis was obtained with freshly prepared intestinal fluid solutions. High performance size exclusion chromatography analysis indicated that the bulk plasticizer completely disappeared and that low molecular weight oligomers were formed within 4 h. Hydrolysis did not result in a significant conversion to the free monomers, like adipic acid, as was shown by gas‐phase chromatography. Measurements by NMR indicated that the cleavage selectively occurred at primary ester linkages. Fractionation of the hydrolysis products on silica gel gave six oligomeric fractions, which were recovered and analyzed. The absolute molecular weight of the plasticizers and the average molecular weight of the hydrolysis products were evaluated using proton NMR. Hydrolysis did not take place (<2%) under simulated gastric and saliva conditions. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 956–966, 2002</description><subject>Applied sciences</subject><subject>Compounding ingredients</subject><subject>digestive fluid simulants</subject><subject>Exact sciences and technology</subject><subject>food packaging</subject><subject>hydrolysis</subject><subject>oligomers</subject><subject>pancreatin</subject><subject>Plasticizers</subject><subject>Polymer industry, paints, wood</subject><subject>polymeric plasticizer</subject><subject>regulation</subject><subject>Technology of polymers</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNp10EtLKzEUB_AgV7BXBT9CNsLdjOYxM-m4k15bBdGKr2U4zaNEp50hZ3yMn96UFsWFi3Ag53f-iz8hB5wdccbEMbTtkRCq2CIDziqV5aUY_iGDtOLZsKqKHfIX8YkxzgtWDsjLLXjX9RQQHeLCLTvaeNo2db9wMRgK1oYuvDqkvonpNZa2YJ5hHpbzE3re25goBvx51daAXTDhw0Wks57aMHe4iqG-fgkW98i2hxrd_mbukvvx2d3oPLu8nlyMTi8zIyUvstJbq3huvSqYtMowAZUocyNmuQTpXfoTM3DDyhjDlRXWzJgEISQrhkp4IXfJv3WuiQ1idF63MSwg9pozvapLp7r0qq5ED9e0BTRQ-whLE_Db56lMUZXJZWv3FmrX_5qnT6fTTe7GB-zc-5eH-KxLJRN8vJroGzUdjf8_XOmJ_AR1LYr_</recordid><startdate>20020131</startdate><enddate>20020131</enddate><creator>Hamdani, M.</creator><creator>Thil, L.</creator><creator>Gans, G.</creator><creator>Feigenbaum, A. 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Fractionation of the hydrolysis products on silica gel gave six oligomeric fractions, which were recovered and analyzed. The absolute molecular weight of the plasticizers and the average molecular weight of the hydrolysis products were evaluated using proton NMR. Hydrolysis did not take place (<2%) under simulated gastric and saliva conditions. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 83: 956–966, 2002</abstract><cop>New York</cop><pub>Wiley Periodicals, Inc</pub><doi>10.1002/app.2275</doi><tpages>11</tpages></addata></record> |
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| source | Wiley-Blackwell Journals |
| subjects | Applied sciences Compounding ingredients digestive fluid simulants Exact sciences and technology food packaging hydrolysis oligomers pancreatin Plasticizers Polymer industry, paints, wood polymeric plasticizer regulation Technology of polymers |
| title | Safety assessment of polymeric additives for food packaging: Hydrolysis of polymeric plasticizers by digestive fluids |
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