The synergistic effect of polysorbate 80 upon the toxicity of tri-n-butyltin chloride

Polysorbate 80 (Tween 80) was used as an emulsifying agent for administering tri‐n‐butyltin chloride (TBTCl) to rats below, at and above the LD50 for the compound. Tween 80 greatly enhanced the toxicity of the organotin compound. The LD50 in the presence of Tween 80 (16% of the emulsion) is less tha...

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Veröffentlicht in:	Applied organometallic chemistry 1990-07, Vol.4 (4), p.379-381
Hauptverfasser:	Sherman, Larry R, Kellner, Ginny L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Medical sciences Metals and various inorganic compounds Polysorbate 80 toxicity Toxicology tri-n-butyltin chloride
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Beschreibung
Zusammenfassung:	Polysorbate 80 (Tween 80) was used as an emulsifying agent for administering tri‐n‐butyltin chloride (TBTCl) to rats below, at and above the LD50 for the compound. Tween 80 greatly enhanced the toxicity of the organotin compound. The LD50 in the presence of Tween 80 (16% of the emulsion) is less than half of the LD50 when the TBTCl was administered in corn oil.
ISSN:	0268-2605 1099-0739
DOI:	10.1002/aoc.590040411