Relationship of cytotoxic groups in organotin molecules and the effectiveness of the compounds against leukemia
Cytotoxicity of organotin compounds is assessed and their effectiveness against leukemia is discussed. The functional groups attached to the tin atom in organotin compounds control the cytotoxicity of the compound towards the thymus gland. The four organotin moieties which have the greatest toxic ef...
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| Veröffentlicht in: | Applied organometallic chemistry 1988, Vol.2 (1), p.65-72 |
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| container_title | Applied organometallic chemistry |
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| creator | Sherman, Larry R Huber, Friedo |
| description | Cytotoxicity of organotin compounds is assessed and their effectiveness against leukemia is discussed. The functional groups attached to the tin atom in organotin compounds control the cytotoxicity of the compound towards the thymus gland. The four organotin moieties which have the greatest toxic effect upon the thymus gland are the tri‐n‐butyltin, di‐n‐butyltin, tri‐n‐propyltin and di‐n‐octyltin groups. Compounds containing these groups also exhibit the poorest test‐control ratio (T/C) values when tested as anti‐cancer agents against leukemic mice using NCI protocol. |
| doi_str_mv | 10.1002/aoc.590020109 |
| format | Article |
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The functional groups attached to the tin atom in organotin compounds control the cytotoxicity of the compound towards the thymus gland. The four organotin moieties which have the greatest toxic effect upon the thymus gland are the tri‐n‐butyltin, di‐n‐butyltin, tri‐n‐propyltin and di‐n‐octyltin groups. Compounds containing these groups also exhibit the poorest test‐control ratio (T/C) values when tested as anti‐cancer agents against leukemic mice using NCI protocol.</description><identifier>ISSN: 0268-2605</identifier><identifier>EISSN: 1099-0739</identifier><identifier>DOI: 10.1002/aoc.590020109</identifier><identifier>CODEN: AOCHEX</identifier><language>eng</language><publisher>Essex: Longman Group UK Ltd</publisher><subject>Biological and medical sciences ; cytotoxicity ; General pharmacology ; Medical sciences ; Organotin compounds ; P388 leukemia ; Pharmacology. Drug treatments ; Physicochemical properties. Structure-activity relationships ; thymus gland</subject><ispartof>Applied organometallic chemistry, 1988, Vol.2 (1), p.65-72</ispartof><rights>Copyright © 1988 Longman Group UK Ltd.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2679-5af06f7b65fa2702ec0219efda7fd8a66a448032b0cf7c095ba195abf9abc4133</citedby><cites>FETCH-LOGICAL-c2679-5af06f7b65fa2702ec0219efda7fd8a66a448032b0cf7c095ba195abf9abc4133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Faoc.590020109$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Faoc.590020109$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,4022,27922,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7634556$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Sherman, Larry R</creatorcontrib><creatorcontrib>Huber, Friedo</creatorcontrib><title>Relationship of cytotoxic groups in organotin molecules and the effectiveness of the compounds against leukemia</title><title>Applied organometallic chemistry</title><addtitle>Appl. Organometal. Chem</addtitle><description>Cytotoxicity of organotin compounds is assessed and their effectiveness against leukemia is discussed. The functional groups attached to the tin atom in organotin compounds control the cytotoxicity of the compound towards the thymus gland. The four organotin moieties which have the greatest toxic effect upon the thymus gland are the tri‐n‐butyltin, di‐n‐butyltin, tri‐n‐propyltin and di‐n‐octyltin groups. Compounds containing these groups also exhibit the poorest test‐control ratio (T/C) values when tested as anti‐cancer agents against leukemic mice using NCI protocol.</description><subject>Biological and medical sciences</subject><subject>cytotoxicity</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Organotin compounds</subject><subject>P388 leukemia</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. Structure-activity relationships</subject><subject>thymus gland</subject><issn>0268-2605</issn><issn>1099-0739</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNp9kElPwzAQhS0EEmU5cveBa2Cy2K6PbcUqoAiB4GZNHLsYkjiKE6D_nlStKk5cZkaj770ZPUJOYjiLAZJz9PqMyWGCGOQOGQ1VRiBSuUtGkPBxlHBg--QghA8AkDzORsQ_mRI75-vw7hrqLdXLznf-x2m6aH3fBOpq6tsF1r4bpsqXRvelCRTrgnbvhhprje7cl6lNCCuD1VL7qvF9XQzYAl0dOlqa_tNUDo_InsUymONNPyQvlxfPs-vobn51M5vcRTrhQkYMLXArcs4sJgISoyGJpbEFCluMkXPMsjGkSQ7aCg2S5RhLhrmVmOssTtNDEq19detDaI1VTesqbJcqBrVKSw1pqW1aA3-65hsMGkvbYq1d2IoETzPG-ICJNfbtSrP831NN5rO_BzYPudCZn60S20_FRSqYen24Uk-PU_Z2O71U9-kvy0GMsA</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Sherman, Larry R</creator><creator>Huber, Friedo</creator><general>Longman Group UK Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1988</creationdate><title>Relationship of cytotoxic groups in organotin molecules and the effectiveness of the compounds against leukemia</title><author>Sherman, Larry R ; Huber, Friedo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2679-5af06f7b65fa2702ec0219efda7fd8a66a448032b0cf7c095ba195abf9abc4133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Biological and medical sciences</topic><topic>cytotoxicity</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>Organotin compounds</topic><topic>P388 leukemia</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemical properties. Structure-activity relationships</topic><topic>thymus gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sherman, Larry R</creatorcontrib><creatorcontrib>Huber, Friedo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><jtitle>Applied organometallic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sherman, Larry R</au><au>Huber, Friedo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of cytotoxic groups in organotin molecules and the effectiveness of the compounds against leukemia</atitle><jtitle>Applied organometallic chemistry</jtitle><addtitle>Appl. Organometal. Chem</addtitle><date>1988</date><risdate>1988</risdate><volume>2</volume><issue>1</issue><spage>65</spage><epage>72</epage><pages>65-72</pages><issn>0268-2605</issn><eissn>1099-0739</eissn><coden>AOCHEX</coden><abstract>Cytotoxicity of organotin compounds is assessed and their effectiveness against leukemia is discussed. The functional groups attached to the tin atom in organotin compounds control the cytotoxicity of the compound towards the thymus gland. The four organotin moieties which have the greatest toxic effect upon the thymus gland are the tri‐n‐butyltin, di‐n‐butyltin, tri‐n‐propyltin and di‐n‐octyltin groups. Compounds containing these groups also exhibit the poorest test‐control ratio (T/C) values when tested as anti‐cancer agents against leukemic mice using NCI protocol.</abstract><cop>Essex</cop><pub>Longman Group UK Ltd</pub><doi>10.1002/aoc.590020109</doi><tpages>8</tpages></addata></record> |
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| ispartof | Applied organometallic chemistry, 1988, Vol.2 (1), p.65-72 |
| issn | 0268-2605 1099-0739 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_aoc_590020109 |
| source | Wiley Online Library All Journals |
| subjects | Biological and medical sciences cytotoxicity General pharmacology Medical sciences Organotin compounds P388 leukemia Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships thymus gland |
| title | Relationship of cytotoxic groups in organotin molecules and the effectiveness of the compounds against leukemia |
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