Development of Generic G Protein Peptidomimetics Able to Stabilize Active State G s Protein-Coupled Receptors for Application in Drug Discovery

G protein-coupled receptors (GPCRs) represent an important group of membrane proteins that play a central role in modern medicine. Unfortunately, conformational promiscuity hampers full therapeutic exploitation of GPCRs, since the largest population of the receptor will adopt a basal conformation, w...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Angewandte Chemie International Edition 2021-04, Vol.60 (18), p.10247-10254
Hauptverfasser:	Mannes, Morgane, Martin, Charlotte, Triest, Sarah, Pia Dimmito, Marilisa, Mollica, Adriano, Laeremans, Toon, Menet, Christel J, Ballet, Steven
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!