Functional Genome Mining Reveals a Class V Lanthipeptide Containing a d-Amino Acid Introduced by an F 420 H 2 -Dependent Reductase

Lantibiotics are a type of ribosomally synthesized and post-translationally modified peptides (termed lanthipeptides) with often potent antimicrobial activity. Herein, we report the discovery of a new lantibiotic, lexapeptide, using the library expression analysis system (LEXAS) approach. Lexapeptid...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-10, Vol.59 (41), p.18029-18035
Hauptverfasser:	Xu, Min, Zhang, Fei, Cheng, Zhuo, Bashiri, Ghader, Wang, Jing, Hong, Jiali, Wang, Yemin, Xu, Lijun, Chen, Xuefei, Huang, Sheng-Xiong, Lin, Shuangjun, Deng, Zixin, Tao, Meifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - chemistry Bacteriocins - chemistry Genome Oxidoreductases - chemistry Peptides - chemistry
Online-Zugang:	Volltext
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