Mitochondrial-DNA-Targeted Ir III -Containing Metallohelices with Tunable Photodynamic Therapy Efficacy in Cancer Cells

The development of DNA-targeted photodynamic therapy (PDT) agents for cancer treatment has drawn substantial attention. Herein, the design and synthesis of dinuclear Ir -containing luminescent metallohelices with tunable PDT efficacy that target mitochondrial DNA in cancer cells are reported. The me...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-04, Vol.59 (16), p.6420-6427
Hauptverfasser:	Li, Xuezhao, Wu, Jinguo, Wang, Lei, He, Cheng, Chen, Liyong, Jiao, Yang, Duan, Chunying
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Binding Sites Cell Line, Tumor Coordination Complexes - chemistry Coordination Complexes - metabolism Coordination Complexes - pharmacology Crystallography, X-Ray DNA, Mitochondrial - chemistry DNA, Mitochondrial - metabolism Humans Iridium - chemistry Light Microscopy, Confocal Mitochondria - drug effects Mitochondria - metabolism Molecular Conformation Molecular Docking Simulation Reactive Oxygen Species - metabolism Stereoisomerism
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