Cover Picture: Crystal Structure of a Cisplatin-(1,3-GTG) Cross-Link within DNA Polymerase η (Angew. Chem. Int. Ed. 17/2010)

Cisplatin–DNA lesions block the transcription of DNA and lead to cell death. In their Communication on page 3077 ff., T. Carell and co‐workers describe the crystal structure of a cisplatin–(1,3‐GTG) intrastrand cross‐link in complex with polymerase η. The movement of this enzyme along the DNA duplex...

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Veröffentlicht in:	Angewandte Chemie International Edition 2010-04, Vol.49 (17), p.2949-2949
Hauptverfasser:	Reißner, Thomas, Schneider, Sabine, Schorr, Stephanie, Carell, Thomas
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Sprache:	eng
Schlagworte:	antitumor agents cisplatin DNA damage polymerases translesion synthesis
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description	Cisplatin–DNA lesions block the transcription of DNA and lead to cell death. In their Communication on page 3077 ff., T. Carell and co‐workers describe the crystal structure of a cisplatin–(1,3‐GTG) intrastrand cross‐link in complex with polymerase η. The movement of this enzyme along the DNA duplex is blocked, in particular by the conformation of the central dT unit of the lesion.
doi_str_mv	10.1002/anie.201001594
format	Article
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subjects	antitumor agents cisplatin DNA damage polymerases translesion synthesis
title	Cover Picture: Crystal Structure of a Cisplatin-(1,3-GTG) Cross-Link within DNA Polymerase η (Angew. Chem. Int. Ed. 17/2010)
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