Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles

Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification al...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2009-01, Vol.48 (13), p.2308-2312
Hauptverfasser:	Asati, Atul, Santra, Santimukul, Kaittanis, Charalambos, Nath, Sudip, Perez, J. Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Cell Line, Tumor cerium Cerium - chemistry Fluorescent Dyes - chemistry Humans immunoassays Kinetics Metal Nanoparticles - chemistry nanotechnology oxidases oxidation Oxidation-Reduction Oxidoreductases - metabolism Polymers - chemistry
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.200805279