Synthesis and Properties of PNA/DNA Chimeras

Synthesis and Properties of PNA/DNA Chimeras

Unambiguous binding to complementary DNA and RNA, stability toward 3′‐exonucleases, and a similar uptake by cells as DNA oligomers characterize the PNA/DNA chimeras of type 1 described here. These chimeric oligomers are accessible in an automated synthesis sequence.

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Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 1996-12, Vol.35 (22), p.2632-2635
Hauptverfasser: Uhlmann, Eugen, Will, David W., Breipohl, Gerhard, Langner, Dietrich, Ryte, Antonina
Format: Artikel
Sprache:eng
Schlagworte:
antisense oligonucleotides
helices
nucleic acids
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Beschreibung
Zusammenfassung:Unambiguous binding to complementary DNA and RNA, stability toward 3′‐exonucleases, and a similar uptake by cells as DNA oligomers characterize the PNA/DNA chimeras of type 1 described here. These chimeric oligomers are accessible in an automated synthesis sequence.
ISSN:0570-0833
1521-3773
DOI:10.1002/anie.199626321