Carbon-Hydrogen Bonds of DNA Sugar Units as Targets for Chemical Nucleases and Drugs

This review article focuses on the molecular aspects of DNA cleavage by synthetic chemical nucleases (transition metal complexes endowed with redox properties and DNA affinity) and natural drugs (cytotoxic agents such as bleomycins or enediynes). Unlike deoxyribonucleases, which catalyze the nucleop...

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Veröffentlicht in:	Angewandte Chemie International Edition 1995-04, Vol.34 (7), p.746-769
Hauptverfasser:	Pratviel, Geneviève, Bernadou, Jean, Meunier, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	bleomycin DNA cleavage Drug research enediynes transition metal complexes
Online-Zugang:	Volltext
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