The Absolute Configuration of (+)-α-1,2,3,4,5,6-Hexachlorocyclohexane, and Its Permeation through the Seal Blood-Brain Barrier
Not the result of enzymatic degradation processes, but of the “preferential permeability” of the blood–brain barrier for (+)‐α‐hexachlorocyclohexane (HCH)—this is the interpretation of the selective accumulation of this enantiomer in seal brain. This conclusion could be drawn only after the α‐HCH is...
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| Veröffentlicht in: | Angewandte Chemie (International ed.) 1994-05, Vol.33 (8), p.882-884 |
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| container_end_page | 884 |
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| container_issue | 8 |
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| container_title | Angewandte Chemie (International ed.) |
| container_volume | 33 |
| creator | Möller, Kattrin Bretzke, Cornelia Hühnerfuss, Heinrich Kallenborn, Roland Kinkel, Jochen N. Kopf, Jürgen Rimkus, Gerhard |
| description | Not the result of enzymatic degradation processes, but of the “preferential permeability” of the blood–brain barrier for (+)‐α‐hexachlorocyclohexane (HCH)—this is the interpretation of the selective accumulation of this enantiomer in seal brain. This conclusion could be drawn only after the α‐HCH isomers were successfully separated on a chiral phase by HPLC. The structure of the (+) enantiomer was determined by X‐ray crystallography, but the structural elements responsible for the selective transfer are still unknown. |
| doi_str_mv | 10.1002/anie.199408821 |
| format | Article |
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| identifier | ISSN: 0570-0833 |
| ispartof | Angewandte Chemie (International ed.), 1994-05, Vol.33 (8), p.882-884 |
| issn | 0570-0833 1521-3773 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_anie_199408821 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Medical sciences Pesticides, fertilizers and other agrochemicals toxicology Toxicology |
| title | The Absolute Configuration of (+)-α-1,2,3,4,5,6-Hexachlorocyclohexane, and Its Permeation through the Seal Blood-Brain Barrier |
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