Enantioselective Catalytic Addition of Functionalized Dialkylzinc Compounds to β-Stannylated Aldehydes: A Convenient Preparation of Chiral β- and γ-Functionalized Secondary Alcohols

Enantioselective Catalytic Addition of Functionalized Dialkylzinc Compounds to β-Stannylated Aldehydes: A Convenient Preparation of Chiral β- and γ-Functionalized Secondary Alcohols

High enantioselectivity is found in the Ti‐catalyzed addition of dialkylzinc compounds [R1(CH2)n]2Zn to the β‐stannylaldehydes 1 and 2 to give the polyfunctionalized products 3 and 4, respectively. Examples of (CH2)nR1: ethyl, octyl, (CH2)4Cl. R = Me, Bu.

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Veröffentlicht in:Angewandte Chemie (International ed.) 1993-04, Vol.32 (4), p.582-584
Hauptverfasser: Brieden, Walter, Ostwald, Roswitha, Knochel, Paul
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Sprache:eng
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Aliphatic compounds
Chemistry
Exact sciences and technology
Organic chemistry
Preparations and properties
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container_title Angewandte Chemie (International ed.)
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creator Brieden, Walter
Ostwald, Roswitha
Knochel, Paul
description High enantioselectivity is found in the Ti‐catalyzed addition of dialkylzinc compounds [R1(CH2)n]2Zn to the β‐stannylaldehydes 1 and 2 to give the polyfunctionalized products 3 and 4, respectively. Examples of (CH2)nR1: ethyl, octyl, (CH2)4Cl. R = Me, Bu.
doi_str_mv 10.1002/anie.199305821
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subjects Aliphatic compounds
Chemistry
Exact sciences and technology
Organic chemistry
Preparations and properties
title Enantioselective Catalytic Addition of Functionalized Dialkylzinc Compounds to β-Stannylated Aldehydes: A Convenient Preparation of Chiral β- and γ-Functionalized Secondary Alcohols
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