Enediyne Compounds Equipped with Acid-, Base- and Photo-Sensitive Triggering Devices. Chemical Simulation of the Dynemicin A Reaction Cascade
Even under very mild basic conditions, the NH compound 2 is generated from the enediyne 1. Compound 2 proved too labile to be isolated, but could be trapped with nucleophiles such as PhOH and PhSH, resulting in the formation of the dibenzo compounds 4 (via 3), among other products. Compounds 2—like...
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| Veröffentlicht in: | Angewandte Chemie International Edition 1991-08, Vol.30 (8), p.1032-1036 |
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| container_title | Angewandte Chemie International Edition |
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| creator | Nicolaou, K. C. Dai, W.-M. Wendeborn, S. V. Smith, A. L. Torisawa, Y. Maligres, P. Hwang, C.-K. |
| description | Even under very mild basic conditions, the NH compound 2 is generated from the enediyne 1. Compound 2 proved too labile to be isolated, but could be trapped with nucleophiles such as PhOH and PhSH, resulting in the formation of the dibenzo compounds 4 (via 3), among other products. Compounds 2—like several other newly synthesized compounds—exhibits DNA‐cleaving activity. |
| doi_str_mv | 10.1002/anie.199110321 |
| format | Article |
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| language | eng |
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| source | Wiley Online Library All Journals |
| title | Enediyne Compounds Equipped with Acid-, Base- and Photo-Sensitive Triggering Devices. Chemical Simulation of the Dynemicin A Reaction Cascade |
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