Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin

Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin

Constitution and conformation determine the biological activity of a peptide, as demonstrated by comparative investigations of the inhibition of cholate uptake in liver cells by somatostatin, antamanide, cyclolinopeptide A and 1 and 2. The crystal structure of 1 is the same as that of 2 over a wide...

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Veröffentlicht in:Angewandte Chemie International Edition 1986-11, Vol.25 (11), p.997-999
Hauptverfasser: Kessler, Horst, Klein, Mechtild, Müller, Arndt, Wagner, Klaus, Bats, Jan Willem, Ziegler, Kornelia, Frimmer, Max
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container_issue 11
container_start_page 997
container_title Angewandte Chemie International Edition
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creator Kessler, Horst
Klein, Mechtild
Müller, Arndt
Wagner, Klaus
Bats, Jan Willem
Ziegler, Kornelia
Frimmer, Max
description Constitution and conformation determine the biological activity of a peptide, as demonstrated by comparative investigations of the inhibition of cholate uptake in liver cells by somatostatin, antamanide, cyclolinopeptide A and 1 and 2. The crystal structure of 1 is the same as that of 2 over a wide range and both react strongly cytoprotectively.
doi_str_mv 10.1002/anie.198609971
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title Conformational Prerequisites for the in vitro Inhibition of Cholate Uptake in Hepatocytes by Cyclic Analogues of Antamanide and Somatostatin
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