Improved Reactive Oxygen Species Generation by Chiral Co 3 O 4 Supraparticles under Electromagnetic Fields
One of the most common methods to treat thromboembolism is the use of thrombolytic drugs to activate fibrinolytic protease. The aim of this treatment was to initiate the lysis of fibrin; however, there are many side‐effects associated with this form of treatment. Herein, we fabricated chiral Co 3 O...
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| Veröffentlicht in: | Angewandte Chemie 2021-08, Vol.133 (33), p.18388-18394 |
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| container_title | Angewandte Chemie |
| container_volume | 133 |
| creator | Wang, Xiuxiu Sun, Maozhong Qu, Aihua Wang, Weiwei Lu, Meiru Guo, Xiao Chen, Chen Hao, Changlong Xu, Liguang Xu, Chuanlai Kuang, Hua |
| description | One of the most common methods to treat thromboembolism is the use of thrombolytic drugs to activate fibrinolytic protease. The aim of this treatment was to initiate the lysis of fibrin; however, there are many side‐effects associated with this form of treatment. Herein, we fabricated chiral Co
3
O
4
supraparticles (SPs) with a g‐factor of up to 0.02 at 550 nm and paramagnetic performance applied in the treatment of thromboembolism under an electromagnetic field (MF). In vitro experiments showed that
d
‐SPs degraded blood clot within 8 hours under MF. Compared to
l
‐SPs,
d
‐SPs exhibited much stronger thrombolytic ability and effectively enhanced the survival rate of thrombosis model mice more than 70 % in the 25 d of observation. The results of mechanism study showed that under MF, the level of reactive oxygen species (ROS) produced by
d
‐SPs were 1.5 times higher than that of
l
‐SPs, which might be attributed to the chiral‐induced spin selectivity effects. |
| doi_str_mv | 10.1002/ange.202105675 |
| format | Article |
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3
O
4
supraparticles (SPs) with a g‐factor of up to 0.02 at 550 nm and paramagnetic performance applied in the treatment of thromboembolism under an electromagnetic field (MF). In vitro experiments showed that
d
‐SPs degraded blood clot within 8 hours under MF. Compared to
l
‐SPs,
d
‐SPs exhibited much stronger thrombolytic ability and effectively enhanced the survival rate of thrombosis model mice more than 70 % in the 25 d of observation. The results of mechanism study showed that under MF, the level of reactive oxygen species (ROS) produced by
d
‐SPs were 1.5 times higher than that of
l
‐SPs, which might be attributed to the chiral‐induced spin selectivity effects.</description><identifier>ISSN: 0044-8249</identifier><identifier>EISSN: 1521-3757</identifier><identifier>DOI: 10.1002/ange.202105675</identifier><language>eng</language><ispartof>Angewandte Chemie, 2021-08, Vol.133 (33), p.18388-18394</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c845-c7b1bdf70320cac9ae2a21761198f2485f5e289899befc909ef2d65df7ecab7e3</citedby><cites>FETCH-LOGICAL-c845-c7b1bdf70320cac9ae2a21761198f2485f5e289899befc909ef2d65df7ecab7e3</cites><orcidid>0000-0003-1784-0420</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids></links><search><creatorcontrib>Wang, Xiuxiu</creatorcontrib><creatorcontrib>Sun, Maozhong</creatorcontrib><creatorcontrib>Qu, Aihua</creatorcontrib><creatorcontrib>Wang, Weiwei</creatorcontrib><creatorcontrib>Lu, Meiru</creatorcontrib><creatorcontrib>Guo, Xiao</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Hao, Changlong</creatorcontrib><creatorcontrib>Xu, Liguang</creatorcontrib><creatorcontrib>Xu, Chuanlai</creatorcontrib><creatorcontrib>Kuang, Hua</creatorcontrib><title>Improved Reactive Oxygen Species Generation by Chiral Co 3 O 4 Supraparticles under Electromagnetic Fields</title><title>Angewandte Chemie</title><description>One of the most common methods to treat thromboembolism is the use of thrombolytic drugs to activate fibrinolytic protease. The aim of this treatment was to initiate the lysis of fibrin; however, there are many side‐effects associated with this form of treatment. Herein, we fabricated chiral Co
3
O
4
supraparticles (SPs) with a g‐factor of up to 0.02 at 550 nm and paramagnetic performance applied in the treatment of thromboembolism under an electromagnetic field (MF). In vitro experiments showed that
d
‐SPs degraded blood clot within 8 hours under MF. Compared to
l
‐SPs,
d
‐SPs exhibited much stronger thrombolytic ability and effectively enhanced the survival rate of thrombosis model mice more than 70 % in the 25 d of observation. The results of mechanism study showed that under MF, the level of reactive oxygen species (ROS) produced by
d
‐SPs were 1.5 times higher than that of
l
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3
O
4
supraparticles (SPs) with a g‐factor of up to 0.02 at 550 nm and paramagnetic performance applied in the treatment of thromboembolism under an electromagnetic field (MF). In vitro experiments showed that
d
‐SPs degraded blood clot within 8 hours under MF. Compared to
l
‐SPs,
d
‐SPs exhibited much stronger thrombolytic ability and effectively enhanced the survival rate of thrombosis model mice more than 70 % in the 25 d of observation. The results of mechanism study showed that under MF, the level of reactive oxygen species (ROS) produced by
d
‐SPs were 1.5 times higher than that of
l
‐SPs, which might be attributed to the chiral‐induced spin selectivity effects.</abstract><doi>10.1002/ange.202105675</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-1784-0420</orcidid></addata></record> |
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| title | Improved Reactive Oxygen Species Generation by Chiral Co 3 O 4 Supraparticles under Electromagnetic Fields |
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