Proinflammatory cytokines regulate antigen-independent T-cell Activation by two separate calcium-signaling pathways in multiple sclerosis patients

Central nervous system (CNS) lesions typical of multiple sclerosis (MS) are characterized by demyelinating inflammatory infiltrates that contain few CNS antigen‐specific autoreactive T cells and a multitude of pathogenic non‐antigen‐specific mononuclear cells. Here, we report that in patients with M...

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