Tropical spastic paraparesis: A neuroepidemiological study in Colombia
A geographic isolate of tropical spastic paraparesis (TSP) in Tumaco, Colombia, is described. Fifity confirmed cases were identified (29 men, 21 women) with an estimated prevalence rario of 98 cases per 100, 000 population. Patients with identified cases ranged in age from 24 to75 years (mean, 46.5)...
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| Veröffentlicht in: | Annals of neurology 1985-04, Vol.17 (4), p.361-365 |
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| creator | Román, Gustavo C. Román, Lydia N. Spencer, Peter S. Schoenberg, Bruce S. |
| description | A geographic isolate of tropical spastic paraparesis (TSP) in Tumaco, Colombia, is described. Fifity confirmed cases were identified (29 men, 21 women) with an estimated prevalence rario of 98 cases per 100, 000 population. Patients with identified cases ranged in age from 24 to75 years (mean, 46.5). TSP begins with burning feet, leg stiffness, spastic bladder, and, in men, impotence. Patients exhibited leg weakness, spasticity, hyperreflexia, and scissoring gait. Babinski, Chaddock, and Hoffmann signs could elicited. Ankle reflexes and vibratory sensation of the feet were decresed. Intellectual function, coordination, and cranial nerves remained normal. TSP is slowly progressive disorder but so far there have been no deaths from it. Forth cases in this report began between 1971 and 1980; the earliest documented case began in 1952. Living conditions and occupations of the patients were typical for the region. Yaws had occured in 74% of confirmed cases. No likely etiological neurotoxix or nutritional factors identified. TSP aslo has been described in India, Africa, the Seychelles, and Jamaica. |
| doi_str_mv | 10.1002/ana.410170410 |
| format | Article |
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Fifity confirmed cases were identified (29 men, 21 women) with an estimated prevalence rario of 98 cases per 100, 000 population. Patients with identified cases ranged in age from 24 to75 years (mean, 46.5). TSP begins with burning feet, leg stiffness, spastic bladder, and, in men, impotence. Patients exhibited leg weakness, spasticity, hyperreflexia, and scissoring gait. Babinski, Chaddock, and Hoffmann signs could elicited. Ankle reflexes and vibratory sensation of the feet were decresed. Intellectual function, coordination, and cranial nerves remained normal. TSP is slowly progressive disorder but so far there have been no deaths from it. Forth cases in this report began between 1971 and 1980; the earliest documented case began in 1952. Living conditions and occupations of the patients were typical for the region. Yaws had occured in 74% of confirmed cases. No likely etiological neurotoxix or nutritional factors identified. TSP aslo has been described in India, Africa, the Seychelles, and Jamaica.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410170410</identifier><identifier>PMID: 4004158</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Colombia ; Female ; Humans ; Male ; Medical sciences ; Middle Aged ; Muscle Spasticity - epidemiology ; Muscle Spasticity - etiology ; Muscle Spasticity - physiopathology ; Nervous system involvement in other diseases. Miscellaneous ; Neurology ; Paralysis - epidemiology ; Paralysis - etiology ; Paralysis - physiopathology ; Time Factors ; Tropical Climate ; Tropical medicine</subject><ispartof>Annals of neurology, 1985-04, Vol.17 (4), p.361-365</ispartof><rights>Copyright © 1985 the American Neurological Association</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4030-4b141b5577e6980ecc6880fe0a708554207e4ff02924bccb1ce09883cff12a063</citedby><cites>FETCH-LOGICAL-c4030-4b141b5577e6980ecc6880fe0a708554207e4ff02924bccb1ce09883cff12a063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410170410$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410170410$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9214848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4004158$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Román, Gustavo C.</creatorcontrib><creatorcontrib>Román, Lydia N.</creatorcontrib><creatorcontrib>Spencer, Peter S.</creatorcontrib><creatorcontrib>Schoenberg, Bruce S.</creatorcontrib><title>Tropical spastic paraparesis: A neuroepidemiological study in Colombia</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>A geographic isolate of tropical spastic paraparesis (TSP) in Tumaco, Colombia, is described. Fifity confirmed cases were identified (29 men, 21 women) with an estimated prevalence rario of 98 cases per 100, 000 population. Patients with identified cases ranged in age from 24 to75 years (mean, 46.5). TSP begins with burning feet, leg stiffness, spastic bladder, and, in men, impotence. Patients exhibited leg weakness, spasticity, hyperreflexia, and scissoring gait. Babinski, Chaddock, and Hoffmann signs could elicited. Ankle reflexes and vibratory sensation of the feet were decresed. Intellectual function, coordination, and cranial nerves remained normal. TSP is slowly progressive disorder but so far there have been no deaths from it. Forth cases in this report began between 1971 and 1980; the earliest documented case began in 1952. Living conditions and occupations of the patients were typical for the region. Yaws had occured in 74% of confirmed cases. No likely etiological neurotoxix or nutritional factors identified. TSP aslo has been described in India, Africa, the Seychelles, and Jamaica.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Colombia</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Muscle Spasticity - epidemiology</subject><subject>Muscle Spasticity - etiology</subject><subject>Muscle Spasticity - physiopathology</subject><subject>Nervous system involvement in other diseases. Miscellaneous</subject><subject>Neurology</subject><subject>Paralysis - epidemiology</subject><subject>Paralysis - etiology</subject><subject>Paralysis - physiopathology</subject><subject>Time Factors</subject><subject>Tropical Climate</subject><subject>Tropical medicine</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LwzAUx4Moc06PHoUevHa-pGmTeivFbcKYIpMdQ5qlEu0vkg3df2_GSvHk4b0H733ery9CtximGIA8yEZOKQbMwPszNMZxhENOaHqOxhAlNIxxRC_RlXOfAJAmGEZoRMHTMR-j2dq2nVGyClwn3c6ooJNWetPOuMcgCxq9t63uzFbXpq3ajxO7228PgWmC3KfqwshrdFHKyumbPk7Q--xpnS_C5cv8Oc-WoaIQQUgLTHERx4zpJOWglUo4h1KDZMDjmBJgmpYlkJTQQqkCKw0p55EqS0wkJNEEhae5yrbOWV2Kzppa2oPAII5yCC-HGOTw_N2J7_ZFrbcD3f_v6_d9XTr_WGllo4wbsJRgyukRYyfs21T68P9Oka2yvwf0Bxu30z9Dp7RfImERi8VmNRf5G9mw18VC5NEvOxqGVA</recordid><startdate>198504</startdate><enddate>198504</enddate><creator>Román, Gustavo C.</creator><creator>Román, Lydia N.</creator><creator>Spencer, Peter S.</creator><creator>Schoenberg, Bruce S.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>198504</creationdate><title>Tropical spastic paraparesis: A neuroepidemiological study in Colombia</title><author>Román, Gustavo C. ; Román, Lydia N. ; Spencer, Peter S. ; Schoenberg, Bruce S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4030-4b141b5577e6980ecc6880fe0a708554207e4ff02924bccb1ce09883cff12a063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Colombia</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Muscle Spasticity - epidemiology</topic><topic>Muscle Spasticity - etiology</topic><topic>Muscle Spasticity - physiopathology</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Paralysis - epidemiology</topic><topic>Paralysis - etiology</topic><topic>Paralysis - physiopathology</topic><topic>Time Factors</topic><topic>Tropical Climate</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Román, Gustavo C.</creatorcontrib><creatorcontrib>Román, Lydia N.</creatorcontrib><creatorcontrib>Spencer, Peter S.</creatorcontrib><creatorcontrib>Schoenberg, Bruce S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Román, Gustavo C.</au><au>Román, Lydia N.</au><au>Spencer, Peter S.</au><au>Schoenberg, Bruce S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tropical spastic paraparesis: A neuroepidemiological study in Colombia</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1985-04</date><risdate>1985</risdate><volume>17</volume><issue>4</issue><spage>361</spage><epage>365</epage><pages>361-365</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>A geographic isolate of tropical spastic paraparesis (TSP) in Tumaco, Colombia, is described. Fifity confirmed cases were identified (29 men, 21 women) with an estimated prevalence rario of 98 cases per 100, 000 population. Patients with identified cases ranged in age from 24 to75 years (mean, 46.5). TSP begins with burning feet, leg stiffness, spastic bladder, and, in men, impotence. Patients exhibited leg weakness, spasticity, hyperreflexia, and scissoring gait. Babinski, Chaddock, and Hoffmann signs could elicited. Ankle reflexes and vibratory sensation of the feet were decresed. Intellectual function, coordination, and cranial nerves remained normal. TSP is slowly progressive disorder but so far there have been no deaths from it. Forth cases in this report began between 1971 and 1980; the earliest documented case began in 1952. Living conditions and occupations of the patients were typical for the region. Yaws had occured in 74% of confirmed cases. No likely etiological neurotoxix or nutritional factors identified. TSP aslo has been described in India, Africa, the Seychelles, and Jamaica.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>4004158</pmid><doi>10.1002/ana.410170410</doi><tpages>5</tpages></addata></record> |
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| ispartof | Annals of neurology, 1985-04, Vol.17 (4), p.361-365 |
| issn | 0364-5134 1531-8249 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Biological and medical sciences Colombia Female Humans Male Medical sciences Middle Aged Muscle Spasticity - epidemiology Muscle Spasticity - etiology Muscle Spasticity - physiopathology Nervous system involvement in other diseases. Miscellaneous Neurology Paralysis - epidemiology Paralysis - etiology Paralysis - physiopathology Time Factors Tropical Climate Tropical medicine |
| title | Tropical spastic paraparesis: A neuroepidemiological study in Colombia |
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