Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet

The ketogenic diet (KD), a treatment for drug‐resistant epilepsy, elevates brain acetone. Acetone has been shown to suppress experimental seizures. Whether elevation of acetone is the basis of the anticonvulsant effects of the KD and whether acetone, like the KD, antagonizes many different types of...

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Veröffentlicht in:	Annals of neurology 2003-08, Vol.54 (2), p.219-226
Hauptverfasser:	Likhodii, Sergei S., Serbanescu, Irina, Cortez, Miguel A., Murphy, Patricia, Snead III, O. Carter, Burnham, W. McIntyre
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetone - metabolism Acetone - pharmacology Amygdala - physiology Animals Anticonvulsants Anticonvulsants. Antiepileptics. Antiparkinson agents Ataxia - chemically induced Ataxia - psychology Biological and medical sciences Brain Chemistry - drug effects Brain Chemistry - physiology Convulsants Diabetes Mellitus - diet therapy Diet Dose-Response Relationship, Drug Electroshock Epilepsy, Absence - chemically induced Epilepsy, Absence - drug therapy Epilepsy, Complex Partial - chemically induced Epilepsy, Complex Partial - drug therapy Epilepsy, Tonic-Clonic - chemically induced Epilepsy, Tonic-Clonic - drug therapy Kindling, Neurologic - physiology Male Medical sciences Neuropharmacology Pentylenetetrazole Pharmacology. Drug treatments Rats Rats, Wistar trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride - pharmacology
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