The AI‐based AlphaFold 2 algorithm predicts an open structure for tauC3

Background TauC3 is an especially noxious C‐terminal tau fragment produced by caspase‐3 cleavage at Asp421. Two decades of accumulating evidence support its importance in the pathogenesis of AD and other tauopathies, notably FTD and PSP. TauC3 promotes aggregation and filament formation, recruits fu...

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Veröffentlicht in:	Alzheimer's & dementia 2023-12, Vol.19 (S24), p.n/a
Hauptverfasser:	Chain, Daniel G, Margolin, Richard A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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