Efforts toward discovering inhibitors of the SYK SH2–FCER1γ interaction as potential Alzheimer’s disease chemical probes and therapeutics

Background Spleen associated tyrosine kinase (SYK) plays a potential role in several neurodegenerative conditions. To date, a few pharmacological inhibitors have been developed, targeting the ATP‐binding kinase domain, and some of these inhibitors have been reported to show beneficial effects on the...

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Veröffentlicht in:	Alzheimer's & dementia 2023-12, Vol.19 (S21), p.n/a
Hauptverfasser:	Sikdar, Arunima, Bashore, Frances M., Katis, Vittorio, Bradshaw, William, Rygiel, Karolina, Du, Yuhong, Wang, Dongxue, Leisner, Tina, Hardy, Brian P., Kireev, Dmitri B., Pearce, Kenneth H., Fu, Haian, Frye, Stephen V., Axtman, Alison D.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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