AD‐Associated Variants Directly Impair Surface Interactions Between the Hydrophobic Site of TREM2 and the Hinge Region of ApoE

Background Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) and Apolipoprotein E (ApoE) are two of the strongest genetic risk factors for late‐onset Alzheimer’s disease (AD), but while their interplay in the microglial response to AD pathology is hotly studied, surprisingly little is known a...

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Veröffentlicht in:	Alzheimer's & dementia 2023-06, Vol.19 (S1), p.n/a
Hauptverfasser:	Dean, Hunter B, Greer, Rory A, Kober, Daniel L, Roberson, Erik D, Brett, Thomas J, Song, Yuhua
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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